Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System

Figure 4

Cortical electrophysiology following anaesthetised isoguvacine/muscimol dosing. VEP responses in animals ((a)–(d), for each drug group) at anaesthetised baseline (black lines, average of anaesthetised groups) compared to (a) intramuscular and (b) intravitreal isoguvacine (red) and (c) intramuscular and (d) intravitreal muscimol (blue). (e)–(h) summarise VEP parameters (average ± SEM) following isoguvacine or muscimol injections via different routes (see method for details). Grey areas indicate 95% CI of the particular VEP parameter in all anaesthetised baseline recordings. .