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Journal of Ophthalmology
Volume 2016, Article ID 6138659, 8 pages
Research Article

Retinal Vessel Diameters and Their Relationship with Cardiovascular Risk and All-Cause Mortality in the Inter99 Eye Study: A 15-Year Follow-Up

1Center of Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, Oslo, Norway
2Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark
3Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
4Research Center for Prevention and Health, Glostrup, Denmark
5Steno Diabetes Center, Gentofte, Denmark
6Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark

Received 21 July 2016; Revised 13 October 2016; Accepted 25 October 2016

Academic Editor: Stephen Charn Beng Teoh

Copyright © 2016 Dragana Drobnjak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To describe associations between retinal vessel diameters and cardiovascular risk markers and mortality. Methods. The present study included 908 persons aged 30 to 60 years. Vessel diameters were expressed as central retinal venular equivalent (CRVE) and central retinal arteriolar equivalent (CRAE). Multiple linear regression analyses and Cox regression models were used. Results. Multiple linear regression analyses showed that narrower CRAE was associated with higher systolic blood pressure, age, and higher HDL cholesterol, whereas wider CRAE and CRVE were associated with smoking. Narrower CRVE was associated with higher HDL cholesterol. In an age-adjusted model, associations between wider CRVE and risk of ischemic heart disease were found (). Wider CRVE was associated with all-cause mortality (HR = 2.02, ) in a model adjusted for age, gender, and blood pressure. However, the association was not statistically significant after additional adjustment for smoking. Conclusions. The associations between retinal vessel diameters and known cardiovascular risk factors were confirmed. All-cause mortality was not associated with retinal vessel diameters when adjusting for relevant confounders.