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Journal of Ophthalmology
Volume 2016, Article ID 6980281, 9 pages
Review Article

Is Floppy Eyelid Syndrome More Prevalent in Obstructive Sleep Apnea Syndrome Patients?

1Department of Plastic Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Street, Suzhou, Jiangsu 215004, China
2Department of Otolaryngology Surgery, Central Hospital of Fuxin, 74 Zhonghua Street, Fuxin, Liaoning 123000, China
3First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121000, China
4Department of Cerebral-Neuro Surgery, Central Hospital of Fuxin, 74 Zhonghua Street, Fuxin, Liaoning 123000, China
5Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

Received 27 January 2016; Revised 6 March 2016; Accepted 9 May 2016

Academic Editor: Terri L. Young

Copyright © 2016 Ping Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Controversial findings are reported about the relationship between floppy eyelid syndrome (FES) and obstructive sleep apnea syndrome (OSAS). The main goal of this study was to evaluate whether FES is more prevalent in OSAS patients by performing a meta-analysis. A comprehensive literature search of Pubmed, Embase, and Cochrane databases was performed. Only studies related to the prevalence of FES in OSAS were included in the meta-analysis. We estimated a pooled odds ratio (OR) for the prevalence of FES in OSAS. In total, 6 studies with 767 participants met the inclusion criteria. Using a fixed-effects model, the pooled OR was 4.12. The test for the overall effect revealed that FES was statistically prevalent in OSAS patients when compared with that in non-OSAS subjects (, ). In the subgroup analysis by OSAS severity, the incidence of FES in OSAS increased with severity of OSAS as indicated with increased OR values (OR = 2.56, 4.62, and 7.64 for mild, moderate, and severe OSAS). In conclusion, the results indicate that FES is more prevalent in OSAS patients. However, this result was based only on unadjusted estimates. Prospective cohort studies are needed to determine whether OSAS is an independent risk factor for FES.