Journal of Ophthalmology / 2016 / Article / Tab 1

Review Article

Review: The Lacrimal Gland and Its Role in Dry Eye

Table 1

Causes of lacrimal gland dysfunction and their proposed pathological mechanism. Grosscategorization of the most common causes of lacrimal gland dysfunction based on underlying pathology most typical of the disease. HIV, human immunodeficiency virus; CMV, cytomegalovirus.

Pathological changesDisease

Inflammatory/Oxidative StressSjogren’s syndrome
IgG4-related disease
Autoimmune Dacryadenitis
Sarcoidosis
Chronic graft-versus host
Thyroid disease
Orbital inflammatory pseudotumor
Amyotrophic Lateral Sclerosis
Diabetes
Aging

InfectiousHIV
CMV
Hepatitis C

AtrophyAging
Radiation

ToxicityRadiation

EnvironmentalSmoking
Video displays

Autonomic DysfunctionRiley-Day syndrome

Idiopathic