Review: The Lacrimal Gland and Its Role in Dry Eye

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Pathological changes</td><td class="align_left">Disease</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="10">Inflammatory/Oxidative Stress</td><td class="align_left">Sjogren’s syndrome</td></tr><tr><td class="align_left">IgG4-related disease</td></tr><tr><td class="align_left">Autoimmune Dacryadenitis</td></tr><tr><td class="align_left">Sarcoidosis</td></tr><tr><td class="align_left">Chronic graft-versus host</td></tr><tr><td class="align_left">Thyroid disease</td></tr><tr><td class="align_left">Orbital inflammatory pseudotumor</td></tr><tr><td class="align_left">Amyotrophic Lateral Sclerosis</td></tr><tr><td class="align_left">Diabetes</td></tr><tr><td class="align_left">Aging</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="3">Infectious</td><td class="align_left">HIV</td></tr><tr><td class="align_left">CMV</td></tr><tr><td class="align_left">Hepatitis C</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="2">Atrophy</td><td class="align_left">Aging</td></tr><tr><td class="align_left">Radiation</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left">Toxicity</td><td class="align_left">Radiation</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="2">Environmental</td><td class="align_left">Smoking</td></tr><tr><td class="align_left">Video displays</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left">Autonomic Dysfunction</td><td class="align_left">Riley-Day syndrome</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left">Idiopathic</td><td class="align_left"> </td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Causes of lacrimal gland dysfunction and their proposed pathological mechanism.   Grosscategorization of the most common causes of lacrimal gland dysfunction based on underlying pathology most typical of the disease.  HIV, human immunodeficiency virus; CMV, cytomegalovirus.

Journal of Ophthalmology

Review: The Lacrimal Gland and Its Role in Dry Eye

Table 1