Research Article
Different Strategies for the Treatment of Age-Related Macular Degeneration in China: An Economic Evaluation
Table 2
Direct costs
related to AMD treatment and comorbidities.
| Parameters | Median unit cost (range) | Average number (range) | Annual mean total cost | Source |
| Ophthalmologist consultation | 3.2 (0.8–47.6) | 1 time per cycle | 12.8 | [32] | Optical coherence tomography | 31.7 (23.8–39.7) | 1 time per cycle | 126.8 | [32] | Fluorescein angiography | 58.7 (44–73.4) | 2 times per year | 234.8 | [32] | Verteporfin per 15 mg | 2539.7 (1904.8–3174.6) | | | [32] | Laser activation | 238.1 (158.7–317.5) | | | [32] | PDT (verteporfin per 15 mg + laser activation) | | 2.05 (1.5375–2.5625) at 1 year | 5694.5 at 1 year | Calculated | | 1.54 (1.155–1.925) at 2 years | 4277.8 at 2 years | Calculated | Intravitreal injection | 41.3 (31–51.6) | | | Local charge | Ranibizumab per 0.5 mg | 1523.8 (1142.9–1904.8) | 8 (6–12) at 1 year | 12190.4 at 1 year | Local charge | 6 (4.5–12) at 2 years | 9142.8 at 2 years | Bevacizumab per 1.25 mg | 10.5 (7.9–13.1) | 8 (6–12) at 1 year | 84 at 1 year | Local charge | 6 (4.5–12) at 2 years | 63 at 2 years | Adverse reactions | | | | | Endophthalmitis | | | | Local charge | Ranibizumab arm | | 1.4% (1.05%–1.75%) during 1 year | 22.2 | | Bevacizumab arm | | 2.8% (2.1%–3.5%) during 1 year | 44.4 | | Lens damage | | | | Local charge | Ranibizumab arm | | 0.4% (0.3%–0.5%) during 1 year | 6.3 | | Bevacizumab arm | | 0.4% (0.3%–0.5%) during 1 year | 6.3 | | Retinal detachment | | | | Local charge | Ranibizumab arm | | 0.3% (0.23%–0.38%) during 1 year | 5.7 | | Bevacizumab arm | | 0.3% (0.23%–0.38%) during 1 year | 5.7 | | Comorbidities | | | | | Depression | 130.6 (111.2–156.4) | 2.2% (1.65%–2.75%) during 1 year | 3 | Local charge | Fall | 1093.9 (364.6–1823.2) | 18% (14.50%–28.60%) during 1 year | 23 | Local charge | Assisted living | 432.7 (324.5–540.8) | 2.1% (1.58%–2.63%) during 1 year | 77.9 | Local charge |
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Costs are presented as US dollars (January 2015 exchange rate, US = CYN 6.30). The range was used for sensitivity analysis.
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