Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease

Table 2

Intraexaminer repeatability and interexaminer reproducibility of TMH and NIKBUTs in Healthy and DED groups.

Parameters	Healthy ()						Dry eye disease ()
	Mean ± SD	Precision	Repeatability	CV%	ICC	95% CI for ICC	Mean ± SD	Precision	Repeatability	CV%	ICC	95% CI for ICC
Intraexaminer repeatability
TMH (mm)	0.26 ± 0.12	0.10	0.14	18.89	0.84	0.75 to 0.90	0.24 ± 0.08	0.08	0.11	15.96	0.76	0.64 to 0.85
NIKBUT first (s)	7.25 ± 3.45	3.70	5.24	26.10	0.75	0.62 to 0.84	5.77 ± 3.04	2.67	3.76	23.54	0.82	0.73 to 0.89
NIKBUT average (s)	10.61 ± 3.93	3.96	5.60	19.06	0.78	0.66 to 0.86	8.27 ± 3.86	3.04	4.29	18.71	0.85	0.77 to 0.91
Interexaminer reproducibility
TMH (mm)	0.26 ± 0.15	0.10	0.14	19.76	—	—	0.24 ± 0.08	0.08	0.11	16.08	—	—
NIKBUT first (s)	7.35 ± 3.68	2.92	4.13	20.30	—	—	5.87 ± 3.07	2.51	3.55	21.85	—	—
NIKBUT average (s)	10.71 ± 4.11	3.65	5.15	17.37	—	—	8.21 ± 3.93	2.78	3.94	17.30	—	—

SD = standard deviation; TMH = tear meniscus height; NIKBUT = noninvasive Keratograph tear breakup time; CV = coefficient of variation; ICC = intraclass correlation coefficient; 95% CI = 95% confidence interval for the mean.