Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2016 (2016), Article ID 8350134, 7 pages
http://dx.doi.org/10.1155/2016/8350134
Research Article

The Blockade of IL6 Counterparts the Osmolar Stress-Induced Apoptosis in Human Conjunctival Epithelial Cells

1Catholic Institute for Visual Science, Seoul St. Mary’s Hospital, Seoul 06591, Republic of Korea
2Department of Ophthalmology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea

Received 12 January 2016; Accepted 4 May 2016

Academic Editor: Edit Tóth-Molnár

Copyright © 2016 Hee-Jung Ju et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Baudouin, P. Aragona, E. M. Messmer et al., “Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting,” The Ocular Surface, vol. 11, no. 4, pp. 246–258, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. J. P. Gilbard, J. B. Carter, D. N. Sang, M. F. Refojo, L. A. Hanninen, and K. R. Kenyon, “Morphologic effect of hyperosmolarity on rabbit corneal epithelium,” Ophthalmology, vol. 91, no. 10, pp. 1205–1212, 1984. View at Publisher · View at Google Scholar · View at Scopus
  3. J. P. Gilbard, S. R. Rossi, K. L. Gray, L. A. Hanninen, and K. R. Kenyon, “Tear film osmolarity and ocular surface disease in two rabbit models for keratoconjunctivitis sicca,” Investigative Ophthalmology & Visual Science, vol. 29, no. 3, pp. 374–378, 1988. View at Google Scholar · View at Scopus
  4. J. P. Gilbard, S. R. Rossi, K. L. Gray, and L. A. Hanninen, “Natural history of disease in a rabbit model for keratoconjunctivitis sicca,” Acta Ophthalmologica, vol. 67, supplement 192, pp. 95–101, 1989. View at Google Scholar · View at Scopus
  5. S. C. Pflugfelder, S. C. G. Tseng, K. Yoshino, D. Monroy, C. Felix, and B. L. Reis, “Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation,” Ophthalmology, vol. 104, no. 2, pp. 223–235, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. I. K. Gipson and T. Inatomi, “Cellular origin of mucins of the ocular surface tear film,” Advances in Experimental Medicine and Biology, vol. 438, pp. 221–227, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. W.-L. Fei, J.-Q. Chen, X. Du et al., “Dry eye in graft-versus-host disease,” Chinese Journal of Ophthalmology, vol. 39, no. 11, pp. 686–690, 2003. View at Google Scholar · View at Scopus
  8. Y. Ogawa, S. Okamoto, M. Wakui et al., “Dry eye after haematopoietic stem cell transplantation,” British Journal of Ophthalmology, vol. 83, no. 10, pp. 1125–1130, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Igarashi, C. Fujimoto, H. Suzuki et al., “Short-time exposure of hyperosmolarity triggers interleukin-6 expression in corneal epithelial cells,” Cornea, vol. 33, no. 12, pp. 1342–1347, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. M. A. Lemp, C. Baudouin, J. Baum et al., “The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international Dry Eye WorkShop (2007),” The Ocular Surface, vol. 5, no. 2, pp. 75–92, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. K.-C. Yoon, I.-Y. Jeong, Y.-G. Park, and S.-Y. Yang, “Interleukin-6 and tumor necrosis factor-α levels in tears of patients with dry eye syndrome,” Cornea, vol. 26, no. 4, pp. 431–437, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Turner, S. C. Pflugfelder, Z. Ji, W. J. Feuer, M. Stern, and B. L. Reis, “Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion,” Cornea, vol. 19, no. 4, pp. 492–496, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Liu, P.-K. Li, C. Li, and J. Lin, “Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells,” The Journal of Biological Chemistry, vol. 285, no. 35, pp. 27429–27439, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. I. A. Valsero, L. S. Romaní, L. G. Posadas, A. L. García, and Y. Diebold, “IL-6 as a corneal wound healing mediator in an invitro scratch assay,” Experimental Eye Research, vol. 125, pp. 183–192, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. G.-X. Jiang, X.-Y. Zhong, Y.-F. Cui et al., “IL-6/STAT3/TFF3 signaling regulates human biliary epithelial cell migration and wound healing in vitro,” Molecular Biology Reports, vol. 37, no. 8, pp. 3813–3818, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Sakimoto, S. Sugaya, A. Ishimori, and M. Sawa, “Anti-inflammatory effect of IL-6 receptor blockade in corneal alkali burn,” Experimental Eye Research, vol. 97, no. 1, pp. 98–104, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. Z.-Q. Lin, T. Kondo, Y. Ishida, T. Takayasu, and N. Mukaida, “Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice,” Journal of Leukocyte Biology, vol. 73, no. 6, pp. 713–721, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Luo, D.-Q. Li, and S. C. Pflugfelder, “Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways,” Cornea, vol. 26, no. 4, pp. 452–460, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. S. C. Pflugfelder, D. Jones, Z. Ji, A. Afonso, and D. Monroy, “Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca,” Current Eye Research, vol. 19, no. 3, pp. 201–211, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Solomon, D. Dursun, Z. Liu, Y. Xie, A. Macri, and S. C. Pflugfelder, “Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease,” Investigative Ophthalmology and Visual Science, vol. 42, no. 10, pp. 2283–2292, 2001. View at Google Scholar · View at Scopus
  21. D. T. Jones, D. Monroy, Z. Ji, S. S. Atherton, and S. C. Pflugfelder, “Sjogren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium,” Investigative Ophthalmology & Visual Science, vol. 35, no. 9, pp. 3493–3504, 1994. View at Google Scholar · View at Scopus
  22. J. Zhang, X. Yan, and H. Li, “Analysis of the correlations of mucins, inflammatory markers, and clinical tests in dry eye,” Cornea, vol. 32, no. 7, pp. 928–932, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Hebenstreit, J. Horejs-Hoeck, and A. Duschl, “JAK/STAT-dependent gene regulation by cytokines,” Drug News and Perspectives, vol. 18, no. 4, pp. 243–249, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. R. J. Stefan, “Il-6 trans-signaling via the soluble IL-6 receptor: importance for the proinflammatory activities of IL-6,” International Journal of Biological Sciences, vol. 8, no. 9, pp. 1237–1247, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. A. J. Brooks, W. Dai, M. L. O'Mara et al., “Mechanism of activation of protein kinase JAK2 by the growth hormone receptor,” Science, vol. 344, no. 6185, Article ID 1249783, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. J. S. Rawlings, K. M. Rosler, and D. A. Harrison, “The JAK/STAT signaling pathway,” Cell Science, vol. 117, pp. 1280–1283, 2004. View at Publisher · View at Google Scholar
  27. S. C. Afford, J. Pongracz, R. A. Stockley, J. Crocker, and D. Burnett, “The induction by human interleukin-6 of apoptosis in the promonocytic cell line U937 and human neutrophils,” The Journal of Biological Chemistry, vol. 267, no. 30, pp. 21612–21616, 1992. View at Google Scholar · View at Scopus