Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography
Table 2
Comparison of SD-OCT image segmentation values in hydroxychloroquine use and controls.
Thickness (µ)
Hydroxychloroquine use
Control
Mean ± SD
Mean ± SD
value
Central
IS
29.84 ± 6.50
29.43 ± 5.10
0.768
OS
41.25 ± 6.95
48.80 ± 4.05
0.001
IS + OS
71.10 ± 6.73
78.23 ± 3.76
0.001
RPE-BM
38.63 ± 4.39
30.07 ± 2.15
0.001
Nasal
IS
28.71 ± 4.36
29.93 ± 2.84
0.172
OS
27.98 ± 4.41
32.07 ± 2.85
0.001
IS + OS
56.69 ± 5.49
62.00 ± 2.13
0.001
RPE-BM
40.37 ± 4.37
31.53 ± 2.30
0.001
Temporal
IS
28.37 ± 3.60
29.90 ± 3.09
0.055
OS
26.69 ± 4.31
31.67 ± 2.67
0.001
IS + OS
55.06 ± 4.94
61.57 ± 2.30
0.001
RPE-BM
40.12 ± 4.33
31.30 ± 2.44
0.001
Superior
IS
28.00 ± 4.43
29.33 ± 2.31
0.130
OS
26.37 ± 4.50
32.03 ± 2.72
0.001
IS + OS
54.37 ± 5.80
61.37 ± 2.40
0.001
RPE-BM
39.98 ± 4.27
31.03 ± 2.24
0.001
Inferior
IS
28.53 ± 3.75
29.77 ± 2.25
0.105
OS
26.96 ± 4.46
31.70 ± 2.84
0.001
IS + OS
55.49 ± 5.07
61.47 ± 2.16
0.001
RPE-BM
40.12 ± 4.14
31.13 ± 2.16
0.001
IS: inner segment thickness; OS: outer segment thickness; IS + OS: total segment thickness; RPE-BM: retinal pigment epithelium-Bruch’s membrane complex thickness; SD: standard deviation. value adjusted for all the comparisons listed in the table.
