Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography
Table 4
Comparison of SD-OCT image segmentation values in subgroups based on the duration of hydroxychloroquine use.
Hydroxychloroquine use
Thickness (µ)
<5 years
≥5 years
Mean ± SD
Mean ± SD
value
Central
IS
30.85 ± 5.76
28.71 ± 7.19
0.243
OS
42.81 ± 6.20
39.50 ± 7.45
0.089
IS + OS
73.67 ± 6.39
68.21 ± 5.99
0.001
RPE-BM
35.93 ± 2.81
41.67 ± 3.84
0.001
Nasal
IS
29.56 ± 3.86
27.75 ± 4.78
0.141
OS
28.89 ± 4.27
26.96 ± 4.43
0.119
IS + OS
58.44 ± 4.86
54.71 ± 5.57
0.001
RPE-BM
37.41 ± 2.50
43.71 ± 3.53
0.001
Temporal
IS
29.70 ± 3.07
26.88 ± 3.62
0.001
OS
27.59 ± 4.60
25.67 ± 3.80
0.112
IS + OS
57.30 ± 4.49
52.54 ± 4.22
0.001
RPE-BM
37.19 ± 2.63
43.42 ± 3.37
0.001
Superior
IS
28.89 ± 4.66
27.00 ± 4.02
0.129
OS
26.96 ± 4.93
25.71 ± 3.97
0.325
IS + OS
55.85 ± 6.01
52.71 ± 5.17
0.052
RPE-BM
37.22 ± 3.07
43.08 ± 3.17
0.001
Inferior
IS
29.00 ± 3.77
28.00 ± 3.74
0.347
OS
28.48 ± 4.49
25.25 ± 3.82
0.008
IS + OS
57.48 ± 5.15
53.25 ± 3.99
0.001
RPE-BM
37.26 ± 2.64
43.33 ± 3.00
0.001
IS: inner segment thickness; OS: outer segment thickness; IS + OS: total segment thickness; RPE-BM: retinal pigment epithelium-Bruch’s membrane complex thickness; SD: standard deviation. Analysis was performed using Student’s -test. value adjusted for all the comparisons listed in the table.
