Clinical Features and Visual Outcomes of Optic Neuritis in Chinese Children
Table 1
Demographic and clinical characteristics of Chinese children with optic neuritis.
Features
Total
Percent (%)
Number of patients
76
100%
Age at onset, year
Mean
11.80 ± 3.87
Range
5–17
Sex
Male
30
39.5
Female
46
60.5
Experience
76
Unilateral attack
39
51.3
Bilateral attack
37
48.7
Pupillary function test
76
RAPD positive in unilateral
39
100
RAPD positive in bilateral
18
48.65
AQP-4 IgG status
47
Seropositive
13
27.7
Seronegative
34
72.3
Orbit MRI
42
Abnormal (T2 lesions)
35
83.33
Normal
7
16.67
Causes/associations
76
ION
58
76.3
ADEM
1
1.3
MS
3
4.0
SLE
1
1.3
NMOSD
13
17.1
Funduscopy
76
Optic disc edema
22
28.9
Normal
54
71.1
Colour vision test
55
Deficit
11
20
Intact
33
60
Vision too poor to test
11
20
Presenting VA
76
20/40 ≤ VA < 20/20
5
6.6
20/200 ≤ VA < 20/40
34
44.7
CF ≤ VA < 20/200
6
7.9
NLP ≤ VA < CF
31
40.8
Treatment
IV methylprednisolone
76
100
RAPD, relative afferent papillary defect; AQP-4 IgG, anti-aquaporin-4 antibody IgG; ION, isolated optic neuritis; ADEM, acute disseminated encephalomyelitis; MS, multiple sclerosis; SLE, systemic lupus erythematosus; IV, intravenous; VA, best corrected visual acuity; CF, count finger; and NLP, no light perception. Only one eye of each patient was included in the statistical analyses.
