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Journal of Ophthalmology
Volume 2016, Article ID 9213623, 5 pages
Research Article

Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus

1Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Bereketzade Cami Sokak No. 2, Beyoglu, 34420 Istanbul, Turkey
2Department of Ophthalmology, Bagcilar Education and Research Hospital, Mimar Sinan Caddesi, 6. Sokak, Bagcilar, 34100 Istanbul, Turkey

Received 21 February 2016; Revised 1 April 2016; Accepted 4 April 2016

Academic Editor: Tamer A. Macky

Copyright © 2016 Tolga Yilmaz and Ahu Yilmaz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate whether platelet morphology or function is altered in patients with diabetic retinopathy (DR). Methods. This prospective study enrolled 85 healthy controls (HCs) (group 1) and 262 patients with Type 2 diabetes mellitus (T2DM). Patients were subclassified into three groups according to ocular findings: no DR (group 2; ); nonproliferative DR (group 3; ), and proliferative DR (group 4; ). Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT) values, and platelet count were measured in the studied groups. Results. MPV, PDW, and PLCR levels were significantly altered in groups 2–4 compared with HCs (, , ). Compared with group 2, both DR groups had higher MPV and PDW levels, with a significant difference between groups 2 and 4 for both MPV () and PDW (). PLCR correlated with retinopathy stage, but no significant difference was found between the DR groups. Platelet count and PCT values were not significantly different between the groups (). Conclusion. Our findings suggest an association between mean platelet indices (MPI) (i.e., MPV, PDW, and PLCR) and DR stage. Therefore, MPI could be a beneficial prognostic marker of DR in patients with T2DM.