Development of Poly Lactic/Glycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor

Figure 3

Safety assessment of poly lactic/glycolic acid (PLGA) microspheres in a rabbit eye. (a) One or 10 mg PLGA microspheres suspended in 200 μL phosphate buffer solution (PBS) was injected into the anterior chamber, and 1 mg PLGA microspheres suspended in 200 μL PBS was injected into the subconjunctiva. Nine right eyes of 9 rabbits were used for the experiments (). Anterior segments were evaluated by slitlamp microscopy for 14 days. (b, c) Corneal thickness and intraocular pressure were evaluated for 14 days and are shown in the graph. The central corneal thickness was evaluated by ultrasound pachymetry. Intraocular pressure was determined with a Tonovet.

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