Asymmetric Outcomes of Type 1 Retinopathy of Prematurity after Bilateral Intravitreal Ranibizumab Treatment

Table 1

Patient characteristics of infants treated had different outcomes in two eyes.

Cases/gender/; eye	GA; (weeks)	Birth weight (g)	Zone	Stage	Plus	PMA, weeks at; IVR	First appearance of; different outcome; post-IVR (days)	Clinical course	PMA, weeks at; laser treatment	Surgery	Final retinal; reattachment	Follow-up; (months)
1/M/OD	31	1350	I	3	Yes	37	22	Regression first; then recurrence as zone II stage 2 at 42 weeks PMA	43	—	y	28
1/M/OS	31	1350	I	3	Yes	37	22	Marked posterior fibrosis; then S4B at 42 weeks PMA; S5 at 43 weeks PMA	43	LSV at 45 weeks PMA	Partial reattachment	28
2/M/OD	29	1200	I	3	Yes	37	10	Regression first; then recurrence as zone II stage 2 at 43 weeks PMA	43	—	y	30
2/M/OS	29	1200	I	3	Yes	37	10	S5 with marked posterior fibrosis and VH	—	Lensectomy and; vitrectomy at; 57 weeks PMA	n	30
3/F/OD	30	1100	I	3	Yes	35	27	Regression first; then recurrence as zone II stage 2 at 40 weeks PMA	41	—	y	10
3/F/OS	30	1100	I	3	Yes	35	27	Marked posterior preretinal hemorrhage at 38 weeks PMA; then S4B at 56 weeks PMA	41	LSV at 58 weeks PMA	y	10
4/M/OD	28	1000	I	3	Yes	36	18	Regression first; then recurrence as zone II stage 2 at 47 weeks PMA	47	—	y	29
4/M/OS	28	1000	I	3	Yes	36	18	Marked posterior fibrosis and VH then S5 at 47 weeks PMA	47	Lensectomy at; 65 weeks PMA,; vitrectomy at; 104 weeks PMA	n	29
5/M/OD	27	980	I	3	Yes	36	116	Regression of ROP but persistent zone II avascularity	43	—	y	18
5/M/OS	27	980	I	3	Yes	36	116	Regression of ROP but persistent zone II avascularity; then S4A at 52 weeks PMA	43	LSV at 53 weeks PMA	y	18
6/F/OD	27	1100	I	3	Yes	34	63	Regression first; then recurrence as zone II stage 1 at 43 weeks PMA	43	—	y	9
6/F/OS	27	1100	I	3	Yes	34	63	Regression first; then recurrence as zone II stage 2 and severe VH at 43 weeks PMA	43	—	y	9
7/M/OD	31	1380	I	3	Yes	42	9	Regression first; then VH appeared at 43 weeks PMA and continued to progress	43	LSV at 47 weeks PMA	y	8
7/M/OS	31	1380	I	3	Yes	42	9	Regression of ROP but persistent zone II avascularity	43	—	y	8
8/F/OD	31	1200	APROP		Yes	36	22	Regression of ROP	—	—	y	8
8/F/OS	31	1200	APROP		Yes	36	22	Plus regressed but VH progressed to fibrosis at 40 weeks PMA and TRD at 42 weeks PMA	—	LSV at 52 weeks PMA	y	8
9/F/OD	32	1690	II	3	Yes	40	4	Plus sign regressed but peripheral fibrosis progressed and then stage 4A at 42 weeks PMA	41	LSV at 42 weeks PMA	y	11
9/F/OS	32	1690	II	3	Yes	40	4	Regression of ROP but persistent zone II avascularity	41	—	y	11

APROP: aggressive posterior retinopathy of prematurity; F: female; GA: gestational age; LSV: lens-sparing vitrectomy; M: male; OD: right eye; OS: left eye; PMA: postmenstrual age; TRD: tractional retinal detachment; VH: vitreous hemorrhage.