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Journal of Ophthalmology
Volume 2017 (2017), Article ID 1907454, 6 pages
Research Article

Phenotypic Description of the Spanish Multicentre Genetic Glaucoma Group Cohort

1Unidad de Glaucoma, Institut Clínic d’Oftalmologia (ICOF), Hospital Clínic, Barcelona, Spain
2Unidad de Glaucoma y Genética, Institut Comtal d’Oftalmologia, Barcelona, Spain
3Servicio de Laboratorio, Hospital de Terrassa, Barcelona, Spain
4Servicio de Estadística, Hospital Clinic, Barcelona, Spain
5EMEIGG, Spanish Multicentre Glaucoma Group (Estudio Multicéntrico Español de Investigaciones Genéticas en Glaucoma), Spain

Correspondence should be addressed to Elena Milla

Received 14 December 2016; Revised 2 March 2017; Accepted 15 March 2017; Published 26 September 2017

Academic Editor: Carlo Nucci

Copyright © 2017 Elena Milla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The aim of the study was to make a phenotypic description of the Spanish multicentre glaucoma group cohort of patients. Design. Retrospective, observational, multicentre, cohort study. Material and Methods. The clinical charts of 152 patients with hereditary glaucoma from18 Spanish eye centres were reviewed in order to make an epidemiologic description of the type of glaucoma and associated factors. True hereditary cases were compared with familiar cases according to the Gong et al. criteria. Results. 61% were true hereditary cases and 39% familiar cases. Ocular comorbidity, optic disc damage, and visual field mean defect were significantly more severe in hereditary patients, who required significantly more first-line hypotensive drugs and surgical interventions to control intraocular pressure than familiar patients. Conclusions. The strength of the hereditary component of glaucoma seems to worsen the clinical course, causing more structural and functional damage and requiring more intense glaucoma treatment. The family history of glaucoma should be carefully investigated and taken into consideration when making treatment decisions or intensifying previous treatment.