Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2017, Article ID 2407037, 7 pages
https://doi.org/10.1155/2017/2407037
Review Article

Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review

Vall d’Hebron Hospital, Pg de la Vall d’Hebron 119, 08032 Barcelona, Spain

Correspondence should be addressed to Laura N. Distefano; ten.norbehv@onafetsidnl

Received 5 August 2016; Revised 25 November 2016; Accepted 18 January 2017; Published 27 February 2017

Academic Editor: Raffael Liegl

Copyright © 2017 Laura N. Distefano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Global report on diabetes, World Health Organization, France, 1st ed. [ebook] edition, 2016, August 2016, http://www.who.int/diabetes/publications/grd-2016/en/.
  2. L. P. Aiello, T. W. Gardner, G. L. King et al., “Diabetic retinopathy,” Diabetes Care, vol. 21, no. 1, pp. 143–156, 1998. View at Google Scholar
  3. G. Virgili, F. Menchini, V. Murro, E. Peluso, F. Rosa, and G. Casazza, “Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy,” Cochrane Database of Systematic Reviews, vol. 1, Article ID CD008081, 2015. View at Publisher · View at Google Scholar
  4. Early Treatment Diabetic Retinopathy Study Research Group, “Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1,” Archives of Ophthalmology, vol. 103, no. 12, pp. 1796–1806, 1985. View at Google Scholar
  5. Early Treatment Diabetic Retinopathy Study Research Group, “Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2,” Ophthalmology, vol. 94, no. 7, pp. 761–774, 1987. View at Google Scholar
  6. Early Treatment Diabetic Retinopathy Study Research Group, “Focal photocoagulation treatment of diabetic macular edema. Relationship of treatment effect to fluorescein angiographic and other retinal characteristics at baseline: ETDRS report number 19,” Archives of Ophthalmology, vol. 113, no. 9, pp. 1144–1155, 1995. View at Google Scholar
  7. Early Treatment Diabetic Retinopathy Study Research Group, “Techniques for scatter and local photocoagulation treatment of diabetic retinopathy: early treatment diabetic retinopathy study report number 3,” International Ophthalmology Clinics, vol. 27, no. 4, pp. 254–264, 1987. View at Google Scholar
  8. Early Treatment Diabetic Retinopathy Study Research Group, “Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 4,” International Ophthalmology Clinics, vol. 27, no. 4, pp. 265–272, 1987. View at Google Scholar
  9. H. Schatz, D. Madeira, H. R. McDonald, and R. N. Johnson, “Progressive enlargement of laser scars following grid laser photocoagulation for diffuse diabetic macular edema,” Archives of Ophthalmology, vol. 109, no. 11, pp. 1549–1551, 1991. View at Google Scholar
  10. Writing Committee for the Diabetic Retinopathy Clinical Research Network, D. S. Fong, S. F. Strauber et al., “Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema,” Archives of Ophthalmology, vol. 125, no. 4, pp. 469–480, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Romero-Aroca, J. Reyes-Torres, M. Baget-Bernaldiz, and C. Blasco-Sune, “Laser treatment for diabetic macular edema in the 21st century,” Current Diabetes Reviews, vol. 10, no. 2, pp. 100–112, 2014. View at Google Scholar
  12. N. Bhagat, R. A. Grigorian, A. Tutela, and M. A. Zarbin, “Diabetic macular edema: pathogenesis and treatment,” Survey of Ophthalmology, vol. 54, no. 1, pp. 1–32, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. J. Wilson, D. Finkelstein, H. A. Quigley, and W. R. Green, “Macular grid photocoagulation. An experimental study on the primate retina,” Archives of Ophthalmology, vol. 106, no. 1, pp. 100–105, 1988. View at Google Scholar
  14. Diabetic Retinopathy Clinical Research Network, “A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema,” Ophthalmology, vol. 115, no. 9, pp. 1447–1449.e10, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Diabetic Retinopathy Clinical Research, R. W. Beck, A. R. Edwards et al., “Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema,” Archives of Ophthalmology, vol. 127, no. 3, pp. 245–251, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Michaelides, A. Kaines, R. D. Hamilton et al., “A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2,” Ophthalmology, vol. 117, no. 6, pp. 1078–1086.e2, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Rajendram, S. Fraser-Bell, A. Kaines et al., “A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3,” Archives of Ophthalmology, vol. 130, no. 8, pp. 972–979, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. D. V. Do, Q. D. Nguyen, D. Boyer et al., “One-year outcomes of the da Vinci study of VEGF trap-eye in eyes with diabetic macular edema,” Ophthalmology, vol. 119, no. 8, pp. 1658–1665, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. D. M. Brown, U. Schmidt-Erfurth, D. V. Do et al., “Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies,” Ophthalmology, vol. 122, no. 10, pp. 2044–2052, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. Q. D. Nguyen, S. M. Shah, J. S. Heier et al., “Primary end point (six months) results of the ranibizumab for edema of the mAcula in diabetes (READ-2) study,” Ophthalmology, vol. 116, no. 11, pp. 2175–2181.e1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Q. D. Nguyen, S. M. Shah, A. A. Khwaja et al., “Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study,” Ophthalmology, vol. 117, no. 11, pp. 2146–2151, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. D. V. Do, Q. D. Nguyen, A. A. Khwaja et al., “Ranibizumab for edema of the macula in diabetes study: 3-year outcomes and the need for prolonged frequent treatment,” JAMA Ophthalmology, vol. 131, no. 2, pp. 139–145, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Mitchell, F. Bandello, U. Schmidt-Erfurth et al., “The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema,” Ophthalmology, vol. 118, no. 4, pp. 615–625, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. U. Schmidt-Erfurth, G. E. Lang, F. G. Holz et al., “Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema: the RESTORE extension study,” Ophthalmology, vol. 121, no. 5, pp. 1045–1053, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Diabetic Retinopathy Clinical Research Network, M. J. Elman, L. P. Aiello et al., “Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema,” Ophthalmology, vol. 117, no. 6, pp. 1064–1077.e35, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. J. Elman, N. M. Bressler, H. Qin et al., “Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema,” Ophthalmology, vol. 118, no. 4, pp. 609–614, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. M. J. Elman, A. Ayala, N. M. Bressler et al., “Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt vs. Deferred Laser Treatment: 5-year Randomized Trial Results,” Ophthalmology, vol. 122, no. 2, pp. 375–381, 2015. View at Google Scholar
  28. Q. D. Nguyen, D. M. Brown, D. M. Marcus et al., “Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE,” Ophthalmology, vol. 119, no. 4, pp. 789–801, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. D. M. Brown, Q. D. Nguyen, D. M. Marcus et al., “Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE,” Ophthalmology, vol. 120, no. 10, pp. 2013–2022, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. J. A. Wells, A. R. Glassman, A. R. Ayala et al., “Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema: two-year results from a comparative effectiveness randomized clinical trial,” Ophthalmology, vol. 123, no. 6, pp. 1351–1359, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Berger, T. Sheidow, A. F. Cruess, J. D. Arbour, A. S. Courseau, and F. de Takacsy, “Efficacy/safety of ranibizumab monotherapy or with laser versus laser monotherapy in DME,” Canadian Journal of Ophthalmology, vol. 50, no. 3, pp. 209–216, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Chen, W. Li, R. Tzekov, F. Jiang, S. Mao, and Y. Tong, “Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema: a meta-analysis of randomized controlled trials,” PLoS One, vol. 9, no. 12, Article ID e115797, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. J. F. Arevalo, A. F. Lasave, L. Wu et al., “Intravitreal bevacizumab plus grid laser photocoagulation or intravitreal bevacizumab or grid laser photocoagulation for diffuse diabetic macular edema: results of the Pan-american Collaborative Retina Study Group at 24 months,” Retina, vol. 33, no. 2, pp. 403–413, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. K. A. Solaiman, M. M. Diab, and S. A. Dabour, “Repeated intravitreal bevacizumab injection with and without macular grid photocoagulation for treatment of diffuse diabetic macular edema,” Retina, vol. 33, no. 8, pp. 1623–1629, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Barteselli, I. Kozak, S. El-Emam, J. Chhablani, M. A. Cortes, and W. R. Freeman, “12-month results of the standardised combination therapy for diabetic macular oedema: intravitreal bevacizumab and navigated retinal photocoagulation,” The British Journal of Ophthalmology, vol. 98, no. 8, pp. 1036–1041, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Hirano, Y. Toriyama, Y. Iesato et al., “Effect of leaking perifoveal microaneurysms on resolution of diabetic macular edema treated by combination therapy using anti-vascular endothelial growth factor and short pulse focal/grid laser photocoagulation,” Japanese Journal of Ophthalmology, vol. 61, no. 1, pp. 51–60, 2016. View at Publisher · View at Google Scholar