Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases

Figure 3

Clinical research on the use of ROCK-inhibitor Y-27632 eye drops for treatment of corneal decompensation. A representative case of a patient with central corneal edema due to Fuchs endothelial corneal dystrophy is shown. Before treatment, central corneal edema was observed (a), but the corneal edema was eliminated and visual acuity recovered from logMAR 0.70 to −0.18 after 6 months of treatment (b). Reproduced from Okumura et al. [26].

(a) Pre-treatment

(b) Post-treatment