Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases

Figure 4

Pilot clinical research on the use of ROCK inhibitor eye drops for the treatment of acute corneal endothelial damage due to cataract surgery. (a) An 84-year-old female diagnosed with cataract underwent phacoemulsification. During the surgery, the Descemet’s membrane was spontaneously detached from the upper incision tunnel and over 2/3 was aspirated. The patient was referred to the cornea clinic of Kyoto Prefectural University of Medicine due to severe corneal edema. The patient was treated with the 1 mM Y-27632 eye drops for 6 months. At 2 weeks, the cornea had recovered its clarity, and the patient’s visual acuity had improved to 20/20 at 3 months. (b) Panoramic image of the corneal endothelium, evaluated by contact specular microscopy after 3 months. The Descemet’s removal line is indicated as a white dotted line. Reproduced from Okumura et al. [27].

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