Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases

Figure 6

Representative images of the effectiveness of cultured corneal endothelial cell (CEC) injection therapy in clinical research. Representative slit-lamp microscopy images of the first patient, a Japanese female with corneal endothelial decompensation induced by argon laser iridotomy (a). After mechanical removal of an 8 mm diameter section of the corneal endothelium, cultured human CECs together with a ROCK inhibitor were injected into the anterior chamber. Preoperative visual acuity was 0.04 due to the edema in the corneal epithelium and stroma. The postoperative visual acuity recovered to 1.0, together with the associated recovery of corneal transparency (b).

(a) Pre-treatment

(b) Post-treatment