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Journal of Ophthalmology
Volume 2017, Article ID 2651645, 6 pages
Research Article

Long-Term Clinical Course of Normal-Tension Glaucoma: 20 Years of Experience

Department of Ophthalmology, Dong-A University College of Medicine, Busan, Republic of Korea

Correspondence should be addressed to Sang Wook Jin; ten.liamnah@6291tnim

Received 1 September 2016; Accepted 2 March 2017; Published 6 April 2017

Academic Editor: Fritz Hengerer

Copyright © 2017 Sang Wook Jin and Seung Yoon Noh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The purpose of this study was to investigate the long-term clinical course of NTG patients who initiated intraocular pressure- (IOP-) lowering therapy. Methods. The present study included 72 normal-tension glaucoma (NTG) patients. The mean deviation (MD) was measured with visual fields. Nocturnal hypotension with weighted standard deviation (wSD) was determined by 24-hour ambulatory blood pressure monitoring. To identify risk factors for NTG progression, linear logistic regression analysis was employed. Results. The mean follow-up period was 21.2 ± 1.1 years. The mean MD progression rate was −0.28 ± 0.24 dB/year. The mean ocular perfusion pressure (OPP) was 52.1 ± 5.9 mmHg. The mean wSD was 14.5 ± 2.2. In the univariate model, disc hemorrhage (RR 7.12; ), IOP reduction rate (RR 2.12; ), and OPP (RR 1.94; ) were associated with glaucomatous visual field progression. However, in the multivariate model, the IOP reduction rate (RR 2.45; ) and OPP (RR 2.02; ) were detected to be significant factors associated with progression. Conclusions. The mean rate of visual field progression was −0.28 dB/year in NTG patients treated with medical therapy. The IOP reduction rate and OPP were associated with glaucomatous visual field progression.