Long-Term Clinical Course of Normal-Tension Glaucoma: 20 Years of Experience

Table 2

Logistic regression analysis of the association between the clinical parameter and glaucomatous visual field progression.

Variables	Univariate model; RR (95% CI)	value	Multivariate model; RR (95% CI)	value
Female sex	1.97 (0.52–4.39)	0.859	2.04 (0.50–5.32)	0.442
Age	1.27 (0.78–2.12)	0.682	1.12 (0.75–3.02)	0.248
CCT	0.34 (0.12–1.92)	0.897	0.42 (0.22–2.93)	0.617
Baseline IOP	0.87 (0.71–1.82)	0.537	0.57 (0.41–1.52)	0.313
Mean IOP	0.77 (0.67–1.54)	0.265	0.92 (0.57–1.44)	0.331
IOP reduction rate	1.12 (0.95–2.92)	0.045	1.45 (0.83–2.43)	0.048
Disc hemorrhage	7.12 (4.57–13.29)	0.004	8.11 (3.53–16.33)	0.051
Baseline MD	1.02 (0.88–2.36)	0.518	1.56 (0.83–2.39)	0.501
Sys. nocturnal hypotension	0.69 (0.52–1.54)	0.248	0.73 (0.42–1.64)	0.243
Dia. nocturnal hypotension	1.25 (1.01–3.92)	0.254	1.15 (0.95–4.12)	0.319
OPP	1.94 (0.97–3.12)	0.027	2.02 (0.84–3.92)	0.004
wSD	1.01 (0.71–1.78)	0.362	1.32 (0.61–2.15)	0.321

Expressed as the mean ± SD; bolded values indicate statistical significance; RR: relative risk; CI: confidence interval; CCT: central corneal thickness; IOP: intraocular pressure; MD: mean deviation; Sys.: systolic; Dia.: diastolic; OPP: ocular perfusion pressure; wSD: weighted standard deviation.