The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis

Figure 1

Receiver operating characteristic (ROC) curves for discriminating between the healthy and glaucomatous eyes. (a) The area under ROC curves was 0.98, 0.92, and 0.79 for estimated retinal ganglion cell (RGC) count, average retinal nerve fiber layer (RNFL) thickness, and standard automated perimetry mean deviation (SAP MD), respectively. (b) When eyes with MD < −6 dB were excluded, estimated RGC count also showed better diagnostic performance (area under ROC curves of 0.97, 0.88, and 0.75; ). Black line: estimated RGC count; dashed line: average RNFL thickness; dotted line: SAP MD.

(a)

(b)