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Journal of Ophthalmology
Volume 2017 (2017), Article ID 2841408, 5 pages
Research Article

Effect of Mitomycin C on Myopic versus Astigmatic Photorefractive Keratectomy

1College of Applied Medical Science, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia
2Faculty of Medicine, Ain Shams University, Ramses St., Abbasia, Cairo 191566, Egypt

Correspondence should be addressed to Ashwag A. Almosa

Received 17 January 2017; Accepted 27 February 2017; Published 14 March 2017

Academic Editor: Edward Manche

Copyright © 2017 Ashwag A. Almosa and Samah M. Fawzy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided into simple myopia with/without MMC and myopic astigmatism with/without MMC groups. Haze, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), subjective refraction, and K-reading were evaluated at 1-, 3-, 6-, and 12-month follow-ups. Results. One hundred fifty-nine eyes of 80 subjects (34 women and 46 men; mean age, 26.81 ± 7.74 years; range, 18–53 years; spherical powers, −0.50 to −8.00 DS; and cylindrical powers, −0.25 to −5.00 DC) were enrolled. One year postoperatively, the simple myopia with/without MMC groups showed no difference in UCVA (), BCVA (), or spherical equivalent () and a significant difference () in K-reading; the haze formation difference was nonsignificant (). Astigmatic groups with/without MMC showed a significant difference in K-reading (). MMC groups had less haze formation (). Conclusion. PRK with intraoperative MMC application showed excellent visual outcomes. MMC’s effect on astigmatic patients was significantly better with acceptable safety and minimal side effects.