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Journal of Ophthalmology
Volume 2017, Article ID 2915261, 10 pages
Review Article

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia

Yanli Liu,1,2 Yi Dong,3 and Kanxing Zhao1,3,4,5

1Clinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, China
2Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, 8 Guangchuan Road, Tianjin 301800, China
3Tianjin Eye Hospital, 4 Gansu Road, Tianjin 300020, China
4Tianjin Key Laboratory of Ophthalmology and Visual Science, 4 Gansu Road, Tianjin 300020, China
5Tianjin Eye Institute, 4 Gansu Road, Tianjin 300020, China

Correspondence should be addressed to Kanxing Zhao; moc.361.piv@0624xkz

Received 18 January 2017; Accepted 23 March 2017; Published 19 June 2017

Academic Editor: Mehmet Borazan

Copyright © 2017 Yanli Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. Methods. Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for choroidal-associated changes. We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity. Results. Eleven cross-sectional studies that included a total of 768 participants were identified. The amblyopic eye SFCT was thicker than that of the fellow and control (normal) eyes (, 95% CI of 30.22 to 68.27, ; , 95% CI of 32.17 to 76.85, ). There were no differences between the fellow and control eyes (, 95% CI of 1.16 to 28.77, ). Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity. Conclusions. The CT in the amblyopic eyes was thicker than that in the fellow and control eyes.