When Is Evidence Enough Evidence? A Systematic Review and Meta-Analysis of the Trabectome as a Solo Procedure in Patients with Primary Open-Angle Glaucoma

Table 1

Reported pre- and postoperative IOP and number of glaucoma medications for POAG cases undergoing Trabectome as a solo procedure.

Author, year	Time point	N	Mean IOP (mmHg (SD))	IOPR%	SEIOPR%	N	Mean number of medications (mean (SD))	Mean reduction in number of medications
Ting et al. [14]	Baseline	450	25.5 (7.9)	—	—	450	2.73 (1.33)	—
	1 day	450	16.5 (7.9)	35%	44%	450	2.21 (1.73)	0.52
	1 month	420	18.1 (5.8)	29%	38%	420	2.50 (1.45)	0.23
	3 months	384	17.6 (5.3)	31%	37%	384	2.34 (1.42)	0.39
	6 months	327	17.3 (4.0)	32%	35%	327	2.14 (1.34)	0.59
	12 months	293	16.8 (3.9)	34%	35%	293	2.16 (1.29)	0.57
Mizoguchi et al. [15]	Baseline	82	23.5 (7.2)	—	—	43	2.8 (0.8)	—
	6 months	74	16.2 (3.4)	31%	34%	37	2.5 (0.9)	0.3
	12 months	60	15.7 (3.0)	33%	33%	29	2.4 (0.8)	0.4
	18 months	43	15.3 (2.4)	35%	32%	23	2.5 (0.7)	0.3
	24 months	22	14.1 (2.2)	40%	32%	8	1.8 (1.0)	1
Pahlitzsch et al. [12]	Baseline	—	19.8 (5.9)	—	—	—	Not available	—
	12 months	—	14.8 (3.2)	25%	34%	—	2.1 (1.2)	—
Akil et al. [16]	Baseline	18	24.2 (4.7)	—	—	18	2.6 (1.2)	—
	1 month	18	14.6 (3.2)	40%	23%	18	1.7 (1.2)	0.9

IOP: intraocular pressure; IOPR%: percentage reduction in intraocular pressure; SE_IOPR%: standard error of percentage reduction in intraocular pressure. IOP refers to intraocular pressure and SD refers to standard deviation.