Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy

Figure 3

Pedigree and ocular features of family 3. Daytona wide-field color fundus photos and OCT scans of the proband (II:2) at the age of 19 years with bilateral exudative manifestation of FEVR stage 4A. Peripheral retinal signs of cryo treatment and Argon laser barrage, performed after evidence of fluorangiographic leakage, can be seen in the inferior temporal sectors in both eyes. Daytona wide-field color fundus photographs of the proband’s mother (I:2), showing treatment with Argon laser in the retinal periphery of both eyes. Angiograms from the posterior pole and from the midperiphery do not present signs of disease’s activity after laser treatment. Documented clinical evaluation; E+ and E−, positive and negative to genetic test, respectively; RE, right eye; LE, left eye.