Research Article
Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study
Table 1
Baseline characteristics of middle-aged and older patients.
| | Baseline characteristics | Frequency | Middle-aged group (age < 65 years) | Elderly group (age ≥ 65 years) | value |
| | Total patients | 76 | 68 | 8 | — | | Age at onset (years) | Average | 55.53 ± 8.29 (45–83) | 53.28 ± 5.05 (45–65) | 74.75 ± 4.56 (72–83) | NS | | Gender n (%) | Male | 44 (57.9) | 30 (44.1) | 2 (25) | NS | | Female | 32 (42.1) | 38 (55.9) | 6 (75) | | Laterality, n (%) | Unilateral | 53 (69.7) | 49 (72.1) | 4 (50) | NS | | Bilateral | 23 (30.3) | 19 (27.9) | 4 (50) | | Pain, n (%) | Present | 25 (53.2) | 22 (50.0) | 3 (100) | NS | | Absent | 22 (46.8) | 22 (50.0) | 0 (0) | | Initial disc appearance, n (%) | Present | 30 (40.5) | 29 (50.0) | 1 (87.5) | NS | | Absent | 44 (59.5) | 37 (50.0) | 7 (12.5) | | Autoimmune antibodies, n (%) | Normal | 43 (67.2) | 38 (67.9.0) | 5 (67.2) | NS | | Abnormal | 21 (21.8) | 18 (32.1) | 3 (32.8) | | AQP4 antibody, n (%) | Seropositive | 10 (20.4) | 10 (22.2) | 0 (0) | NS | | Seronegative | 39 (79.6) | 35 (77.8) | 4 (100.0) | | CSF study, n (%) | Normal | 23 (50.0) | 23 (51.1) | 0 (0) | NS | | Abnormal | 23 (50.0) | 22 (48.9) | 1 (100.0) | | Orbit MRI, n (%) | Normal | 9 (17.0) | 7 (14.9) | 2 (33.3) | NS | | Abnormal | 44 (83.0) | 40 (85.1) | 4 (66.7) | | Head MRI, n (%) | Normal | 26 (52.0) | 25 (55.6) | 1 (20.0) | NS | | Abnormal | 24 (48.0) | 20 (44.4) | 4 (80.0) | | Relapse rate (N/Y) | Average | 0.46 ± 0.23 (0.14–1) | 0.46 ± 0.23 | 0.44 ± 0.18 | NS |
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CSF: cerebrospinal fluid; AQP4-Ab: anti-aquaporin-4 antibody; MRI: magnetic resonance imaging.
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