Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes

Figure 2

(A1) LC-MS chromatography of the aqueous humor of one patient who did not receive oral resveratrol. (A2) LC-MS chromatography of standard solution of resveratrol, its major three metabolites, and carbamazepine (internal standard). (A3) LC-MS chromatography of the aqueous humor of one patient who had taken one capsule daily for three days before tissue extraction. (B1) LC-MS chromatography of the vitreous humor of one patient who did not receive oral resveratrol. (B2) LC-MS chromatography of standard solution of resveratrol, its three major metabolites, and carbamazepine (internal standard). (B3) LC-MS chromatography of the vitreous humor of one patient who had taken one capsule daily for three days before tissue extraction. (C1) LC-MS chromatography of the conjunctiva of one patient who did not receive oral resveratrol. (C2) LC-MS chromatography of standard solution of resveratrol, its three major metabolites, and carbamazepine (internal standard). (C3) LC-MS chromatography of the conjunctiva of one patient who had taken one capsule daily for three days. 1: resveratrol-4′-O-glucuronide; 2: resveratrol-3-O-glucuronide; 3: resveratrol; 4: resveratrol-3-O-sulfate; and 5: carbamazepine.

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