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Journal of Ophthalmology
Volume 2017, Article ID 4074912, 7 pages
https://doi.org/10.1155/2017/4074912
Research Article

Glaucomatocyclitic Crises May Occur in Patients with Narrow or Closed Angles

1Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
2Department of Ophthalmology, Yuan’s General Hospital, Kaohsiung, Taiwan
3Department of Ophthalmology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
4Department of Ophthalmology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
5Department of Ophthalmology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Correspondence should be addressed to Kwou-Yeung Wu; moc.liamg@0101uweywk

Received 3 August 2017; Accepted 30 October 2017; Published 19 November 2017

Academic Editor: Jesús Pintor

Copyright © 2017 Pei-Kang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To report cases of glaucomatocyclitic crises and discuss the possibility of occurrence in patients with narrow or closed angles. Background. The prevalence of angle closure is much higher among Asians than among the Western population. Currently, there is no evidence for a direct relationship between the etiology and angle structure. Design. A retrospective and observational case series. Methods. We retrospectively collected data from nine adult patients (three males and six females) who were diagnosed with a glaucomatocyclitic crisis and a shallow anterior chamber over a 21-year period, from 1995 to 2016, at the Kaohsiung Medical University Hospital. A narrow angle was defined as a grade less than the Shaffer system grade II. Ophthalmic examinations, including anterior segment biomicroscopy, direct ophthalmoscopy, intraocular pressure measurements, anterior chamber reaction, visual field tests, and the grade of the anterior chamber angle according to the Shaffer system, were reviewed. Results. These patients experienced at least one typical unilateral ocular hypertensive episode that fulfilled the criteria of a glaucomatocyclitic crisis without the angle feature. All patients had gonioscopically narrow or closed angles with or without peripheral anterior synechiae. Conclusions. The coexistence of narrow or closed angles and a glaucomatocyclitic crisis is possible, especially in patients of Asian descent. In patients with shallow anterior chambers, a glaucomatocyclitic crisis may be a cause of acute glaucoma episodes.

1. Introduction

Glaucomatocyclitic crisis, also known as the Posner-Schlossman syndrome (PSS), is a self-limiting, rare disease that was first described by Posner and Schlossman in 1948 [1]. This relatively uncommon disease consists of unilateral recurrent attacks of increased intraocular pressure (IIOP) associated with mild anterior uveitis, a lack of visual field defects, normal optic discs, and an open angle [13]. PSS is classified as a secondary inflammatory glaucoma because uveitis always accompanies the disease [2, 4]. The mild nature of the inflammation at the presentation of the first attack and the rarity of clinical symptoms may cause the disease to be overlooked. Mild nongranulomatous cyclitis may follow acute IIOP by several days; therefore, the etiology of an IIOP episode may be initially unclear. Fine, discrete, round, white keratic precipitates (KP) are characteristic of the disease and may be found on the trabecular meshwork on gonioscopy. Spontaneous resolution of KP may occur within a few weeks [2]. In contrast to the common presentations of severe pain and nausea in acute angle-closure glaucoma episodes, PSS attacks involve only mild discomfort. The affected eye may show mild or no corneal edema with minimal or even no congestion despite marked IIOP. The common symptoms include ocular fullness sensation, blurred vision, or halos. Typically, peripheral anterior synechiae (PAS) or posterior synechiae are uncommon in this disease despite the presence of an anterior chamber reaction [1]. PSS tends to affect young to middle-aged adults between the second and fifth decades [5]. The mean annual incidence and prevalence rates are 0.4 and 1.9 per 100,000 individuals, respectively [6].

The etiology of this disease remains unclear, and potential contributing factors include cytomegalovirus infection [7, 8], autonomic defects/dysregulation [1, 9, 10], autoimmune disease [1113], herpes simplex virus infection [14, 15], Helicobacter pylori infection [16], and insufficient ocular blood supply due to peripheral vascular endotheliopathy [17]. The depth of the anterior chamber may decrease with age, especially in Asians [18]. Clinically, we observed that some patients who were diagnosed with typical PSS with a wide, open angle and suffered from recurrent attacks also had a narrow or closed angle due to aging. The possible etiology mentioned above does not directly relate to angle structure. Therefore, we hypothesized that PSS may occur in patients with a narrow or closed angle.

In this article, we present several cases of glaucomatocyclitic crises with narrow or closed angles.

2. Materials and Methods

The study consisted of consecutive, retrospective, observational case reviews. The described research adhered to the principles of the Declaration of Helsinki, 1964. We retrospectively collected data from patients who were diagnosed with glaucomatocyclitic crises and a shallow anterior chamber at the Kaohsiung Medical University Hospital over a twenty-one-year period from 1995 to 2016. All patients underwent ophthalmic examinations, including anterior segment biomicroscopy, direct ophthalmoscopy, and intraocular pressure (IOP) measurements. IOP was measured by the standard Goldmann applanation tonometry. Visual field tests were performed after the alleviation of IIOP. The angle was examined with an indirect single mirror goniolens and graded by the Shaffer system. A narrow angle was defined as a grade of less than the Shaffer system grade II.

3. Results

Nine patients (three males and six females) were enrolled in the study (Table 1). These patients had at least one typical unilateral ocular hypertensive episode that fulfilled the criteria of glaucomatocyclitic crisis (Table 2, Figures 1 and 2) without the angle feature. All patients demonstrated mild anterior uveitis with fine white KP when the recurrent glaucomatocyclitic-like episodes happened. There was no sign of uveitis between the episodes. They all had a gonioscopically narrow or closed angle with or without PAS (Figures 3 and 4). No atrophic iris change was detected in these cases. Six patients were first diagnosed with PSS at the time of the ocular hypertensive episodes, but narrow angles were subsequently found gonioscopically by a glaucoma specialist (cases 1, 2, 4, 5, 6, and 8). Three patients had received preventive laser iridotomies for occludable angles before the ocular hypertensive episodes occurred, but glaucomatocyclitic-like attacks occurred afterwards (cases 3, 7, and 9). All patients received laser iridotomies on both eyes after narrow angles were identified, before or after the glaucomatocyclitic-like episodes. The uveitic work up including human leukocyte antigen (HLA) B27 and antinuclear antibodies (ANA) was collected in cases 1, 2, and 8. All the results were negative. All patients were not on long-term glaucoma medications before the first episode. During follow-up, three patients (cases 1, 2, and 3) needed long-term glaucoma medications for the control of IOP due to subsequent glaucoma and progression of visual field defect.

Table 1: Demographic data and a brief description of ocular examinations.
Table 2: Primary description of glaucomatocyclitic crises by Posner and Schlossman [1, 3].
Figure 1: Small, discrete, round, well-defined, white keratic precipitates on the cornea. Red arrows indicate fine, discrete, round, white keratic precipitates on the endothelium of case 2 (a), case 8 (b), and case 9 (c).
Figure 2: Relatively clear corneas were noted when glaucomatocyclitic crises occurred. The images of case 8 ((a) IOP = 50 mmHg) and case 9 ((b) IOP = 39 mmHg) revealed relatively minimal corneal edema when episodes of acute increased intraocular pressure occurred. IOP = intraocular pressure.
Figure 3: A narrow angle was identified according to the Van Herick technique. Shallow anterior chamber depth was identified through an anterior segment biomicroscopy examination using the Van Herick technique in case 2 (a) and case 8 (b).
Figure 4: Example of angle structure images. The Shaffer system grade I angle structure was noted on an indirect single mirror goniolens in case 8 (a, b) before receiving laser peripheral iridotomy.

4. Discussion

Glaucomatocyclitic crisis was first reported and described by Posner and Schlossman decades ago [1, 3]. In their report, a series of 9 patients with ocular hypertension shared the same characteristics (Table 2). PSS typically occurs in individuals aged 20–50 years. However, an atypical episode in a 13-year-old adolescent [19] as well as attacks in adults older than 60 years has been reported. PSS is generally considered a benign disease. Neither development of PAS nor posterior synechiae is a classical symptom of PSS [1]. IIOP is typically disproportionate to the inflammatory reaction of the anterior chamber and precedes the reaction by several days. Fine, discrete, round, white KP may be found on the trabecular meshwork.

Most PSS patients adequately treated for acute episodes of IOP elevation completely recover without long-term sequelae, while a portion of patients may develop glaucomatous optic nerve damage and various visual field defects after repeated events [20]. However, treatment during remission is not necessary because the frequency of further attacks is not influenced by unremitting treatment. In 1973, Kass et al. established a positive association between glaucomatocyclitic crisis and primary open angle glaucoma (POAG) in an observation of eleven patients. They reported up to 45% concomitance between PSS and POAG [21]. Jap et al. also found that 26.4% of PSS patients developed glaucomatous optic nerve damage [20].

A number of cases have been reported with some deviation from the primary descriptions by Posner and Schlossman, such as a bilateral simultaneous presentation [22, 23], prominent iris processes, anterior displacement of Schwalbe’s line, or a fine membrane over the trabecular meshwork [24, 25], although the presence of angle abnormalities is not considered a typical diagnostic characteristic by some experts. However, no previous studies have challenged the open angle concept.

In 2007, Green reported on a 47-year-old Vietnamese male initially diagnosed with acute angle-closure glaucoma and subsequently with PSS [5]. After receiving laser iridotomy in the affected eye, the patient suffered from several episodes of IIOP with mild conjunctival hyperemia, a few fine KP, and mild cyclitis with wide open angles (Schaffer grades 3 to 4) on gonioscopy. However, the diagnosis of PSS was challenged by the author because sectoral iris atrophy was identified in this case, and the Fuchs heterochromic iridocyclitis may have been an alternative diagnosis.

The definite causes of PSS remain unclear. To date, no evidence has shown a direct relationship between the etiology and angle structure. The prevalence of angle closure is much higher among Asians than among the Western population, and a more rapid decline in angle width measurements is apparent with age in the general population [18]. Asians also have a higher prevalence of primary angle-closure glaucoma [2628], and the risk factors include Asian descent [2931], older age [29, 32], and shorter axial length [33]. Therefore, it is reasonable that glaucomatocyclitic episodes occur in Asian patients with narrow angles.

However, presentation with a narrow or closed angle inevitably raises concerns that IIOP episodes might simply be induced by subacute or intermittent angle-closure attacks, which also tend to be less painful and produce milder symptoms. We excluded this possibility because the IIOP attacks recurred even after patent laser iridotomies. After laser iridotomies, the gonioscopy exam revealed open angles and no evidence of iridotrabecular contact, except preexisting sporadic PAS in 4 cases (cases 1, 3, 4, and 9). Furthermore, by reviewing the charts, we found that a mydriatic agent was used for retina examinations in some patients, and no angle-closure attacks were recorded. Therefore, the plateau iris configuration is also not a likely cause of IIOP in these patients. We believe that the causes of these IIOP attacks are more closely related to their cyclic nature than angle features.

In our case series, the angle structure in individuals of Asian descent, presentation of the IIOP attacks, and findings on gonioscopy combined with the absence of typical symptoms of acute angle closure (severe pain, nausea, vomiting, and corneal edema) indicate that a variant of PSS may occur in patients with a narrow angle. Additionally, our patients tended to be older, which can explain the age-related lens effect on the decline in angle width. In contrast to typical PSS, PAS was present in some of our cases. However, further discussion may be needed to clarify the actual cause of this disease.

5. Conclusions

Based on our clinical observation, it is possible for patients with narrow or closed angles to have glaucomatocyclitic crises, which is different from the primary feature described by Posner and Schlossman. The variance of PSS and the concomitance between PSS and narrow angle/angle closure (suspect), especially in individuals of Asian descent, should be noted. PSS should not be excluded from the diagnosis of patients with acute IIOP episodes, shallow anterior chambers, white KP, patent laser iridotomies, and less severe symptoms, especially in Asians and middle-aged adults.

To the best of our knowledge, this case series is the first to present glaucomatocyclitic crisis episodes in individuals with a narrow angle/angle closure. We reported these cases to indicate the potential coexistence of narrow angle/angle closure, PAS, and glaucomatocyclitic crises.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References

  1. A. Posner and A. Schlossman, “Syndrome of unilateral recurrent attacks of glaucoma with cyclitic symptoms,” Archives of Ophthalmology, vol. 39, no. 4, pp. 517–535, 1948. View at Publisher · View at Google Scholar
  2. R. S. Moorthy, A. Mermoud, G. Baerveldt, D. S. Minckler, P. P. Lee, and N. A. Rao, “Glaucoma associated with uveitis,” Survey of Ophthalmology, vol. 41, no. 5, pp. 361–394, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Posner and A. Schlossman, “Further observations on the syndrome of glaucomatocyclitic crises,” Transactions American Academy of Ophthalmology, vol. 57, no. 4, pp. 531–536, 1953. View at Google Scholar
  4. T. Takahashi, S. Ohtani, K. Miyata, N. Miyata, S. Shirato, and M. Mochizuki, “A clinical evaluation of uveitis-associated secondary glaucoma,” Japanese Journal of Ophthalmology, vol. 46, no. 5, pp. 556–562, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. R. J. Green, “Posner-Schlossman syndrome (glaucomatocyclitic crisis),” Clinical & Experimental Optometry, vol. 90, no. 1, pp. 53–56, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Paivonsalo-Hietanen, J. Tuominen, H. Vaahtoranta-Lehtonen, and K. M. Saari, “Incidence and prevalence of different uveitis entities in Finland,” Acta Ophthalmologica Scandinavica, vol. 75, no. 1, pp. 76–81, 1997. View at Publisher · View at Google Scholar
  7. S. B. Teoh, L. Thean, and E. Koay, “Cytomegalovirus in aetiology of Posner-Schlossman syndrome: evidence from quantitative polymerase chain reaction,” Eye, vol. 19, no. 12, pp. 1338–1340, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Bloch-Michel, E. Dussaix, P. Cerqueti, and D. Patarin, “Possible role of cytomegalovirus infection in the etiology of the Posner-Schlossmann syndrome,” International Ophthalmology, vol. 11, no. 2, pp. 95-96, 1987. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Puri and D. Verma, “Bilateral glaucomatocyclitic crisis in a patient with Holmes Adie syndrome,” Journal of Postgraduate Medicine, vol. 44, no. 3, pp. 76-77, 1998. View at Google Scholar
  10. C. Raitta and A. Vannas, “Glaucomatocyclitic crisis,” Archives of Ophthalmology, vol. 95, no. 4, pp. 608–612, 1977. View at Publisher · View at Google Scholar · View at Scopus
  11. K. E. Eakins, “Increased intraocular pressure produced by prostaglandins E1 and E2 in the cat eye,” Experimental Eye Research, vol. 10, no. 1, pp. 87–92, 1970. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Hirose, S. Ohno, and H. Matsuda, “HLA-Bw54 and glaucomatocyclitic crisis,” Archives of Ophthalmology, vol. 103, no. 12, pp. 1837–1839, 1985. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Masuda, Y. Izawa, and S. Mishima, “Prostaglandins and glaucomatocyclitic crisis,” Japanese Journal of Ophthalmology, vol. 368, p. 19, 1975. View at Google Scholar
  14. S. Yamamoto, D. Pavan-Langston, R. Tada et al., “Possible role of herpes simplex virus in the origin of Posner-Schlossman syndrome,” American Journal of Ophthalmology, vol. 119, no. 6, pp. 796–798, 1995. View at Publisher · View at Google Scholar
  15. H. L. Takusagawa, Y. Liu, and J. L. Wiggs, “Infectious theories of Posner-Schlossman syndrome,” International Ophthalmology Clinics, vol. 51, no. 4, pp. 105–115, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Y. Choi, M. S. Kim, J. M. Kim, S. H. Park, K. H. Park, and C. Hong, “Association between Helicobacter pylori infection and Posner-Schlossman syndrome,” Eye, vol. 24, no. 1, pp. 64–69, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. C. Shen, W. J. Ho, S. C. Wu et al., “Peripheral vascular endothelial dysfunction in glaucomatocyclitic crisis: a preliminary study,” Investigative Ophthalmology & Visual Science, vol. 51, no. 1, pp. 272–276, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. N. G. Congdon, P. J. Foster, S. Wamsley et al., “Biometric gonioscopy and the effects of age, race, and sex on the anterior chamber angle,” The British Journal of Ophthalmology, vol. 86, no. 1, pp. 18–22, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Burnstein, K. Shelton, and E. J. Higginbotham, “Glaucomatocyclitic crisis in a child,” American Journal of Ophthalmology, vol. 126, no. 1, pp. 136-137, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Jap, M. Sivakumar, and S. P. Chee, “Is Posner Schlossman syndrome benign?” Ophthalmology, vol. 108, no. 5, pp. 913–918, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Kass, B. Becker, and A. E. Kolker, “Glaucomatocyclitic crisis and primary open-angle glaucoma,” American Journal of Ophthalmology, vol. 75, no. 4, pp. 668–673, 1973. View at Publisher · View at Google Scholar
  22. P. Levatin, “Glaucomatocyclitic crises occurring in both eyes,” American Journal of Ophthalmology, vol. 41, no. 6, pp. 1056–1059, 1956. View at Publisher · View at Google Scholar
  23. L. K. Hess, G. A. Lee, and P. Shah, “Bilateral simultaneous presentation of Posner-Schlossman syndrome,” Clinical and Experimental Ophthalmology, 2017. View at Publisher · View at Google Scholar
  24. C. T. Hart and J. R. Weatherill, “Gonioscopy and tonography in glaucomatocyclitic crises,” The British Journal of Ophthalmology, vol. 52, no. 9, pp. 682–687, 1968. View at Publisher · View at Google Scholar
  25. G. Gorin, “Developmental glaucoma. A concept based on correlation of gonioscopic findings with clinical manifestations,” American Journal of Ophthalmology, vol. 58, no. 4, pp. 572–580, 1964. View at Publisher · View at Google Scholar
  26. H. A. Quigley and A. T. Broman, “The number of people with glaucoma worldwide in 2010 and 2020,” The British Journal of Ophthalmology, vol. 90, no. 3, pp. 262–267, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. N. G. Congdon, Q. Youlin, H. Quigley et al., “Biometry and primary angle-closure glaucoma among Chinese, white, and black populations,” Ophthalmology, vol. 104, no. 9, pp. 1489–1495, 1997. View at Publisher · View at Google Scholar
  28. S. D. Cassard, H. A. Quigley, E. W. Gower, D. S. Friedman, P. Y. Ramulu, and H. D. Jampel, “Regional variations and trends in the prevalence of diagnosed glaucoma in the Medicare population,” Ophthalmology, vol. 119, no. 7, pp. 1342–1351, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. P. J. Foster, J. Baasanhu, P. H. Alsbirk, D. Munkhbayar, D. Uranchimeg, and G. J. Johnson, “Glaucoma in Mongolia. A population-based survey in Hovsgol Province, Northern Mongolia,” Archives of Ophthalmology, vol. 114, no. 10, pp. 1235–1241, 1996. View at Publisher · View at Google Scholar
  30. N. Nguyen, J. S. Mora, M. M. Gaffney et al., “A high prevalence of occludable angles in a Vietnamese population,” Ophthalmology, vol. 103, no. 9, pp. 1426–1431, 1996. View at Publisher · View at Google Scholar
  31. J. S. Lai, D. T. Liu, C. C. Tham, R. T. Li, and D. S. Lam, “Epidemiology of acute primary angle-closure glaucoma in the Hong Kong Chinese population: prospective study,” Hong Kong Medical Journal, vol. 7, no. 2, pp. 118–123, 2001. View at Google Scholar
  32. S. K. Seah, P. J. Foster, P. T. Chew et al., “Incidence of acute primary angle-closure glaucoma in Singapore. An island-wide survey,” Archives of Ophthalmology, vol. 115, no. 11, pp. 1436–1440, 1997. View at Publisher · View at Google Scholar
  33. R. Sihota, A. Sood, V. Gupta, V. Gupta, T. Dada, and H. C. Agarwal, “A prospective longterm study of primary chronic angle closure glaucoma,” Acta Ophthalmologica Scandinavica, vol. 82, no. 2, pp. 209–213, 2004. View at Publisher · View at Google Scholar · View at Scopus