Research Article

Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes

Table 2

Follow-up characteristics of the patients.

Number of CNV-ME, mean ± SD37.5 ± 6.8
 12 months9.3 ± 2.0
 24 months8.0 ± 2.0
 36 months7.2 ± 2.1
 48 months6.9 ± 1.9
 60 months6.1 ± 2.2
Missed CNV-ME, mean ± SD1.6 ± 1.7
 Due to disease, n (%)111 (59.0)
 Due to unknown reasons, n (%)77 (41.0)
 Patients with at least 1, n (%)78 (66.7)
 Patients with more than 1, n (%)49 (41.9)
Number of injections, mean ± SD21.7 ± 12.4
 12 months6.0 (2.4)
 24 months4.2 (3.1)
 36 months3.7 (3.1)
 48 months4.0 (3.7)
 60 months3.8 (3.7)
Missed injections, n27
 Patients with at least 1, n (%)25 (21.4)
 Patients with more than 1, n (%)2 (1.7)
Treatment suspensions, mean ± SD5.3 ± 3.0
 Due to medical indication, n (%)562 (90.8)
 Without medical indication, n (%)57 (9.2)
Treatment reinitiations, mean ± SD4.7 ± 3.1
 Patients needing further treatment at the end of follow-up, n (%)51 (43.6)
Development of atrophy, n (%)83 (70.9)
 During treatment, n (%)52 (62.7)
 During suspension with medical indication, n (%)31 (37.3)
Development of RPE tear, n (%)9 (7.7)
 During treatment, n (%)8 (88.9)
 During suspension with medical indication, n (%)1 (11.1)
Development of subretinal fibrosis, n (%)75 (68.5)
 During treatment, n (%)61 (81.3)
 During suspension with medical indication, n (%)14 (18.7)
Sudden massive hemorrhages
 Episodes during treatment, n (%)24 (51.1)
 Episodes during suspension with medical indication, n (%)23 (48.9)
 Patients with at least 1 episode, n (%)38 (32.5)
 Patients with more than 1 episode, n (%)9 (7.7)

patients, as 9 people had subretinal fibrosis at baseline. CNV-ME: choroidal neovascularization-medical examinations; RPE: retinal pigment epithelium.