Treatment of Neovascular Age-Related Macular Degeneration with Anti-VEGF Agents: Predictive Factors of Long-Term Visual Outcomes
Table 4
Univariate and multivariate analysis for prediction of visual outcomes at 60 months.
Variables at baseline
BCVA score
ΔBCVA score
BCVA score ≥ 65
ΔBCVA score> 0
Univariate analysis ( value)
Multivariable analysis ( value)
Univariate analysis ( value)
Multivariable analysis ( value)
Univariate analysis ( value)
Multivariable analysis ( value)
Univariate analysis ( value)
Multivariable analysis ( value)
Gender
0.842
—
0.039
0.246
0.161
0.251
0.013
0.014
Age
0.047
0.617
0.109
0.200
0.770
—
0.088
0.016
Treatment delay
0.151
—
0.009
—
0.839
—
0.795
—
Baseline BCVA
<0.001
<0.001
<0.001
<0.001
<0.001
0.001
0.004
<0.001
CNV lesion subtype
0.002
—
0.801
—
0.078
—
0.990
—
CFT
0.003
0.218
0.907
—
0.148
0.781
0.702
—
Subfoveal hemorrhage
0.957
—
0.920
—
1.000
—
0.748
—
Subretinal fibrosis
0.820
—
0.212
—
0.681
—
0.731
—
Variables during follow-up
Number of CNV-ME
0.017
0.533
0.302
—
0.014
0.084
0.259
—
Number of missed CNV-ME
0.822
—
0.901
—
0.919
—
0.980
—
Number of injections
0.002
0.014
0.401
—
0.263
—
0.060
0.018
Number of missed injections
0.064
0.253
0.676
—
0.630
—
0.160
0.233
Number of treatment suspensions
0.078
0.960
0.957
—
0.070
0.954
0.400
—
Development of atrophy
0.113
0.745
0.326
—
0.625
—
0.221
—
Development of RPE tear
0.120
0.226
0.830
—
0.204
—
0.731
—
Development of subretinal fibrosis
<0.001
0.012
0.224
—
0.052
0.123
0.512
—
Number of sudden massive hemorrhages
<0.001
0.075
0.289
—
0.017
0.306
0.278
—
BCVA: best-corrected visual acuity; Δ: variation; CNV: choroidal neovascularization; CFT: central foveal thickness; CNV-ME: choroidal neovascularization medical examination; RPE: retinal pigment epithelium; value was from the following: independent samples Mann–Whitney U test; one-way ANOVA; independent-sample t-test. Pearson chi-square; linear-by-linear association; binomial logistic regression; Fisher’s exact test; variables with in univariate analysis were included in the multivariable analysis; variables with in multivariable analysis were included in the final multivariable model for predictive factors of designated outcome.
