Research Article
Ocular Adverse Effects of Intravitreal Bevacizumab Are Potentiated by Intermittent Hypoxia in a Rat Model of Oxygen-Induced Retinopathy
Figure 1
Effects of Avastin on retinal (a, b), vitreous fluid (c, d), and choroidal (e, f) VEGF levels in adolescent 23-day-old (a, c, and e) and pubertal 45-day-old (b, d, and f) rats exposed to room air (RA), hyperoxia (50% O2), and intermittent hypoxia (IH). Animals exposed to IH received 50% O2 with brief, clustered hypoxia (12% O2) episodes for a total of 8 episodes per day from P0 to P14. Data are presented as mean ± SD ( samples/group). , , versus saline RA; , versus Avastin RA; §, §§, §§§ versus right untreated eye. RE: right eye; LE: left eye.
| (a) |
| (b) |
| (c) |
| (d) |
| (e) |
| (f) |