Ocular Adverse Effects of Intravitreal Bevacizumab Are Potentiated by Intermittent Hypoxia in a Rat Model of Oxygen-Induced Retinopathy

Table 1

Growth parameters.

	Room air (RA)		50% O2		IH (50% O2/12%O2 cycling)
	Saline	Avastin	Saline	Avastin	Saline	Avastin
P23
% change in body weight	745.7 ± 1.3	449.6 ± 16.9^§§	308.7 ± 16.4	524.0 ± 28.8^§§	644.9 ± 16.6	525.4 ± 22.2^§§
% change in length	101.1 ± 1.1	81.8 ± 3.1^§§	77.1 ± 2.8	91.1 ± 2.9^‡§§	94.5 ± 2.4	92.6 ± 3.7^†
Brain/body weight ratio	0.027 ± 0.0006	0.0092 ± 0.091	0.053 ± 0.003	0.04 ± 0.002^§§	0.023 ± 0.0008	0.04 ± 0.0014^§§
Lung/body weight ratio	0.0097 ± 0.0008	0.015 ± 0.002	0.021 ± 0.001	0.016 ± 0.002	0.009 ± 0.0003	0.02 ± 0.0014^‡
P45
% change in body weight	2886.6 ± 111.2	2328.4 ± 76.7^§§	2373.1 ± 109.5	2677.7 ± 109.2^†	2613.2 ± 84.6	2583.2 ± 81.2
% change in length	247.9 ± 4.3	187.8 ± 4.7^§§	193.3 ± 3.5	205.9 ± 3.7^†§	206.8 ± 4.2	193.7 ± 4.3
Brain/body weight ratio	0.041 ± 0.002	0.011 ± 0.003^§§	0.01 ± 0.0003	0.01 ± 0.0003	0.009 ± 0.0003	0.0093 ± 0.004
Lung/body weight ratio	0.091 ± 0.005	0.008 ± 0.0006^§§	0.0062 ± 0.0002	0.0065 ± 0.0003^†	0.006 ± 0.0007	0.005 ± 0.0005^‡

Data are mean ± SD ( per group; versus saline RA; and versus Avastin RA; ^§ and ^§§ versus saline). IH: intermittent hypoxia.