Research Article
Ocular Adverse Effects of Intravitreal Bevacizumab Are Potentiated by Intermittent Hypoxia in a Rat Model of Oxygen-Induced Retinopathy
Table 1
Growth parameters.
| | Room air (RA) | 50% O2 | IH (50% O2/12%O2 cycling) | Saline | Avastin | Saline | Avastin | Saline | Avastin |
| P23 | % change in body weight | 745.7 ± 1.3 | 449.6 ± 16.9§§ | 308.7 ± 16.4 | 524.0 ± 28.8§§ | 644.9 ± 16.6 | 525.4 ± 22.2§§ | % change in length | 101.1 ± 1.1 | 81.8 ± 3.1§§ | 77.1 ± 2.8 | 91.1 ± 2.9‡§§ | 94.5 ± 2.4 | 92.6 ± 3.7† | Brain/body weight ratio | 0.027 ± 0.0006 | 0.0092 ± 0.091 | 0.053 ± 0.003 | 0.04 ± 0.002§§ | 0.023 ± 0.0008 | 0.04 ± 0.0014§§ | Lung/body weight ratio | 0.0097 ± 0.0008 | 0.015 ± 0.002 | 0.021 ± 0.001 | 0.016 ± 0.002 | 0.009 ± 0.0003 | 0.02 ± 0.0014‡ | P45 | % change in body weight | 2886.6 ± 111.2 | 2328.4 ± 76.7§§ | 2373.1 ± 109.5 | 2677.7 ± 109.2† | 2613.2 ± 84.6 | 2583.2 ± 81.2 | % change in length | 247.9 ± 4.3 | 187.8 ± 4.7§§ | 193.3 ± 3.5 | 205.9 ± 3.7†§ | 206.8 ± 4.2 | 193.7 ± 4.3 | Brain/body weight ratio | 0.041 ± 0.002 | 0.011 ± 0.003§§ | 0.01 ± 0.0003 | 0.01 ± 0.0003 | 0.009 ± 0.0003 | 0.0093 ± 0.004 | Lung/body weight ratio | 0.091 ± 0.005 | 0.008 ± 0.0006§§ | 0.0062 ± 0.0002 | 0.0065 ± 0.0003† | 0.006 ± 0.0007 | 0.005 ± 0.0005‡ |
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Data are mean ± SD ( per group; versus saline RA; and versus Avastin RA; § and §§ versus saline). IH: intermittent hypoxia.
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