Ocular Adverse Effects of Intravitreal Bevacizumab Are Potentiated by Intermittent Hypoxia in a Rat Model of Oxygen-Induced Retinopathy

Table 2

Serum levels of VEGF, sVEGFR-1, and IGF-I.

Growth factors	Room air (RA)		50% O2		IH (50% O2/12% O2 cycling)
	Saline	Avastin	Saline	Avastin	Saline	Avastin
P23
VEGF (pg/mL)	79.9 ± 17.6	82.9 ± 25.3	32.7 ± 27.2	19.7 ± 2.3^‡	8.9 ± 10.8	1.01 ± 2.3^‡
sVEGFR-1 (pg/mL)	716.8 ± 130.0	665.7 ± 285.9	594.6 ± 144.0	412.7 ± 51.7^‡§	387.6 ± 99.7	350.3 ± 75.0^‡
IGF-I (pg/mL)	4197.5 ± 33.0	4222.7 ± 99.3	4017.4 ± 152.2	4137 ± 95.2	4222.9 ± 86.7	3151.0 ± 51.8^‡§§
P45
VEGF (pg/mL)	73.3 ± 36.1	33.0 ± 25.2^§	30.8 ± 2.4	17.3 ± 14.6	39.5 ± 20.1	98.5 ± 110.8^‡§§
sVEGFR-1 (pg/mL)	671.8 ± 194.4	623.6 ± 166.4	518.6 ± 154.6	519.9 ± 106.4	304.3 ± 50.5	380.5 ± 124.4^‡
IGF-I (pg/mL)	4044.3 ± 112.1	4018.6 ± 60.8	3985.9 ± 159.3	4036.0 ± 89.1	3214.0 ± 277.3	3144.3 ± 32.7^‡

Data are mean ± SD; and versus saline RA; versus Avastin RA; ^§ and ^§§ versus saline (). IH: intermittent hypoxia.