Ocular Adverse Effects of Intravitreal Bevacizumab Are Potentiated by Intermittent Hypoxia in a Rat Model of Oxygen-Induced Retinopathy
Table 3
Quantitation of retinal vasculature (right eyes).
Room air (RA)
50% O2
IH (50% O2/12% O2 cycling)
Saline
Avastin
Saline
Avastin
Saline
Avastin
P23
Vascular density (%)
35.8 ± 3.6
34.1 ± 6.7§§
33.4 ± 2.1
31.4 ± 3.3
33.5 ± 4.7
25.6 ± 4.5
Total vessel network
23134 ± 7786
18391 ± 4537
15330± 1803
15020 ± 2031†
16141 ± 3644
12867 ± 2292‡§§
Branching points
522.5 ± 41.1
415.5 ± 49.4
316.5 ± 45.4
261.8 ± 59.4‡§§
343.0 ± 33.8
235.3 ± 63.1‡§§
Number of segments
904.0 ± 103.2
732.6 ± 127.2§§
580.8 ± 98.1
493.8 ± 99.7‡§§
619.5 ± 117.5
449.3 ± 109.8‡§§
Mean segment length
26.0 ± 2.8
29.0 ± 1.4§§
26.8 ± 1.7
30.8 ± 3.4§§
27.3 ± 5.3
29.0 ± 2.3
P45
Vascular density (%)
31.3 ± 4.5
33.1 ± 1.8
36.0 ± 3.1
34.5 ± 2.3
36.9 ± 4.4
30.9 ± 4.2§§
Total vessel network
15764 ± 2492
16849 ± 3147
18180 ± 1929
18792 ± 2616
19177 ± 2281
15483 ± 2488§§
Branching points
320.7 ± 83.5
287.8 ± 58.6
401.3 ± 56.0
241.3 ± 65.2§§
451.8 ± 63.4
290.4 ± 68.9§§
Number of segments
599.3 ± 127.4
628.4 ± 127.6
718.3 ± 73.8
711.2 ± 105.0
784.0 ± 140.3
530.0 ± 123.8§§
Mean segment length
26.3 ± 1.2
31.0 ± 4.7§§
25.3 ± 1.5
26.7 ± 4.2†
25.5 ± 3.4
29.7 ± 2.7§§
Data are mean ± SD; , versus saline RA; †, ‡ versus Avastin RA; §§ versus saline ( retinas/group; 12 measurements per group). IH: intermittent hypoxia.
