Ocular Adverse Effects of Intravitreal Bevacizumab Are Potentiated by Intermittent Hypoxia in a Rat Model of Oxygen-Induced Retinopathy
Table 4
Quantitation of retinal vasculature (left eyes).
Room Air (RA)
50% O2
IH (50% O2/12% O2 Cycling)
Saline
Avastin
Saline
Avastin
Saline
Avastin
P23
Vascular density (%)
34.3 ± 3.2
32.5 ± 1.5
32.7 ± 5.1
30.4 ± 6.4
36.2 ± 4.3
31.4 ± 3.4§§
Total vascular area
14928 ± 1332
17045.0 ± 1981§§
15544± 4433
14654 ± 4274†
17963 ± 2611
14339± 2668‡§§
Number of branching points
278.0 ± 13.4
347.3 ± 76.0§§
289.2 ± 103.8
267.8 ± 97.6
407.7 ± 113.1
255.0 ± 71.2†§§
Number of segments
515.7 ± 23.3
622.3 ± 127.6§§
533.2 ± 177.8
512.4 ± 78.1
721.5 ± 178.5
487.8 ± 132.3†§§
Mean segment length
29.0 ± 1.4
27.7 ± 3.1
30.2 ± 4.5
29.8 ± 4.2
25.5 ± 2.7
30.0 ± 3.2§§
P45
Vascular density (%)
34.5 ± 3.4
29.8 ± 4.5
37.9 ± 2.0
31.6 ± 3.3§
38.1 ± 8.1
24.1 ± 5.8‡§§
Total vessel network
17233 ± 2158
16076 ± 2604
22101 ± 5106
17434 ± 3190§
19773 ± 4041
12715 ± 2772†§§
Branching points
364 ± 76.3
277.0 ± 58.6§§
522.8 ± 124.8
347.3 ± 55.8§§
518.0 ± 112.1
198.3 ± 91.0†§§
Number of segments
653.0 ± 119.0
524.0 ± 118.7§§
896.0 ± 187.9
622.5 ± 85.1§§
876.8 ± 222.2
382.8 ± 137.9†§§
Mean segment length
26.8 ± 2.4
27.0 ± 2.1
24.5 ± 0.6
28.3 ± 3.3‡§§
24.5 ± 7
34.5 ± 4.2‡§§
Data are mean ± SD; , versus saline RA; , versus Avastin RA; § and §§ versus saline ( retinas/group; 12 measurements per group). IH: intermittent hypoxia.
