A Masked, Randomized, Phase 3 Comparison of Triple Fixed-Combination Bimatoprost/Brimonidine/Timolol versus Fixed-Combination Brimonidine/Timolol for Lowering Intraocular Pressure

Table 1

Baseline demographics and patient characteristics (modified intent-to-treat population).

Characteristics	TFC ()	DFC ()	value^a
Mean age (SD), years	60.0 (10.2)	58.8 (10.5)	0.411
≤65 years, n (%)	66 (71.0)	74 (76.3)
>65 years, n (%)	27 (29.0)	23 (23.7)
Gender, n (%)			0.151
Male	16 (17.2)	25 (25.8)
Female	77 (82.8)	72 (74.2)
Diagnosis, n (%)			0.505
OHT	32 (34.4)	29 (29.9)
POAG	61 (65.6)	68 (70.1)
Mean baseline IOP, mmHg (SD)	24.6 (2.5)	25.1 (2.2)	0.139
<25, n (%)	57 (61.3)	51 (52.6)
≥25, n (%)	36 (38.7)	46 (47.4)
Concurrent use of systemic β-blockers, n (%)			0.925
Yes	9 (9.7)	9 (9.3)
No	84 (90.3)	88 (90.7)

DFC: dual fixed-combination; IOP: intraocular pressure; OHT: ocular hypertension; POAG: primary open-angle glaucoma; SD: standard deviation; TFC: triple fixed-combination. ^aPearson’s chi-square test.