Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy

Figure 7

OTX008 suppresses retinal neovascularization (RNV) and attenuates retinal hypoxia. (a) RA group. (b) OIR-OTX008 group. (c) OIR group. (d) OIR-PBS group. At P17, whole-mount retinas were stained by isolectin B4 (red) and Hypoxyprobe (green). White arrows indicate neovascular tufts. Black arrows show hypoxic zones. Irregular loops depict VO areas. Magnification 40x, scale . (e–g) Quantification of RNV, vaso-obliteration (VO), and hypoxic zones. RNV, VO, and hypoxia zones were decreased from the OIR-OTX008 group compared to the OIR group and to the OIR-PBS group. RA versus OIR, , , , ; OIR-OTX008 versus OIR, , , , , OIR-OTX008 group versus OIR-PBS group, , , , ; data were presented as the mean ± SD, per group.

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