The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment

Figure 5

Immunohistochemistry of MMP-2 in the cornea at different time points. (A) On day 1, MMP-2 staining was found in the epithelium (indicated by an arrow), 400x; (B) on day 7, MMP-2 expression increased in the epithelium (indicated by an arrow). MMP-2 staining was also found in the boundary of the focal zone, 400x; ((C), (D)) on days 15 and 30, the expression of MMP-2 reached a maximum value, primarily in the epithelium (indicated by an arrow) but also in the stroma, 400x; (E) on day 60, the expression of MMP-2 was reduced, primarily in the epithelium (indicated by an arrow), 400x; (F) on day 90, there was no expression of MMP-2 in the epithelium or stoma, 400x; (G) there was no expression of MMP-2 in the epithelium or stoma in the control group, 400x. Scale bar = 100 μm.