The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats

Figure 1

Histology and FFA results of CNV modeling. (a) Histology of CNV lesions stained with HE shows that CNV formation and broke the Brunch’s membrane at 21 days after photocoagulation. Dome-like CNV complexes, consisting of fibrovascular tissue, retinal pigment epithelial cells, and pigment clumps, are shown and white arrow indicates the vessel lumina of neovascular. (b) FFA results showed fluorescein leakage of CNV in each group at day 14, 21, and 28 (7 days after CM082 treatment) separately. The signal intensity of capillary in background region was defined as “0” whereas the signal intensity of the main branch of the retinal vein was defined as “1”. (c) There is no significant difference between the intensity score of leakage in each group at day 14, 21, and 28 (). Scale bar, 100 μm.

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