Clinical Features and Treatments of Syphilitic Uveitis: A Systematic Review and Meta-Analysis
Table 1
Study characteristics and patient demographics.
Study
Study design
Study period
Geographical location
Number of patients
Number of eyes
Number of dropouts or loss of follow-up
Age (years), range
Males (%)
Ethnicity (%)
Bollemeijier (2016)
Retrospective
1984–2013
Netherlands
85
139
10
47 (27–73)
82.4
Caucasian (78.8), Surinam black (8.2), African American (2.3), Asian (8.2), Surinam Indian (2.3)
Dai (2016)
Retrospective
2011-2012
China
25
41
Unknown
53 (33–70)
72
Chinese (100.0)
Fonollosa (2016)
Retrospective
2000–2012
Spain
50
93
0
41 (19–76)
61
—
Sahin (2016)
Retrospective
2012–2014
Turkey
12
17
0
43.75 (8–67)
58.3
Caucasian (100.0)
Tsuboi (2016)
Retrospective
1997–2015
Japan
20
30
4
41 (32.5–46.5)
100
Japanese (100.0)
Zhang (2016)
Retrospective
2012–2015
China
15
26
0
50 (35–68)
60
Chinese (100.0)
Lee (2015)
Retrospective
2008–2014
USA
16
29
2
48.5 (20–63)
100
Black (25.0), Hispanic (56.2), white (12.5), others (6.2)
Moradi (2015)
Retrospective
1984–2014
USA
35
61
4
45 (24–80)
74.3
African American (60.0), Caucasian (40.0)
Northey (2015)
Retrospective
2007–2012
Australia
25
37
50% lost after 3 months
41 (24–81)
92
—
Shen (2015)
Retrospective
2009–2014
China
13
21
4
50.3 ± 5.9 (37–61)
53.8
Chinese (100.0)
Mathew (2014)
Prospective
2009–2011
UK
41
63
0
47.5 (20.6–75.1)
90.2
Caucasian (90.2), Afro Caribbean (7.1); Arab (2.4)
Rodrigues (2014)
Retrospective
2012 (Mar. to Oct.)
Brazil
12
19
Unknown
38.5 (28–55)
91.6
—
Yap (2014)
Retrospective
2004–2009
Singapore
12
18
2 only at 1 month
49.5 (24–84)
91.7
Chinese (75.0), Malays (16.7), Indian (8.3)
Restivo (2013)
Retrospective
2004–2010
Italy
14
21
0
46.2 ± 10.4 (26–66)
92.9
—
Eandi (2012)
Retrospective
—
USA, Europe
16
25
Unknown
40 (28–57)
87.5
Non-Latino white (93.8), black (6.3)
Yang (2012)
Retrospective
2004–2011
China
19
35
0
41.8 (19–70)
57.9
Asian (100.0)
Balaskas (2011)
Retrospective
1999–2009
Switzerland
26
42
3
45 (33–80)
69.2
Caucasian (80.8), African (15.4), Asian (3.8)
Li (2011)
Retrospective
1991–2009
USA
13
24
1
40 (30–67)
100
—
Hughes (2010)
Retrospective
2006–2009
Australia
13
19
0
41.7 (29–29)
92.3
—
Li (2010)
Retrospective
92% after 2000
Not mentioned
13
22
2-3 probably lost
38 (26–55)
100
—
Kunkel (2009)
Retrospective
1998–2006
Germany
24
41
11
42.4 ± 2.5 (); 41.6 ± 3.0 ()
91.7
—
Fonollosa (2009)
Retrospective
2005–2007
Spain
12
18
0
47 (26–76)
83.3
—
Anshu (2008)
Retrospective
1995–2006
Singapore
22
29
Unknown
52.7 (18–78)
77.3
—
Hong (2007)
Retrospective
1992–2004
Taiwan
8
14
0
57.7 (32–82)
87.5
—
Parc (2007)
Retrospective
2001–2004
France
10
11
6/10 lost after 3 months
41.2 ± 9.9 (28–59)
100
—
Tran (2005)
Retrospective
2001–2003
France
12
20
3
40 (28–56)
100
—
Shalaby (1997)
Retrospective
1983–1995
USA
13
23
5
37 (?–?)
92.3
—
Ormerod (2001)
Retrospective
1990–1993
USA
21
40
2
51 (29–72)
61.9
Black (76.2), no data (23.8)
Browning (2000)
Retrospective
1986–1999
USA
14
24
0
42 (28–69)
71.4
African American (78.6), Caucasian (21.4)
Villanueva (2000)
Retrospective
1993–1996
USA
20
Not mentioned
6
58 ± 14 (29–70)
40
Black (100.0)
Deschenes (1992)
Retrospective
1986–1990
Canada
14
24
Unknown
Mean: 50 for men, 63 for women
64.3
—
Tamesis (1990)
Retrospective
1983–1989
USA
25
36
Unknown
Mean: 47 for men, 57 for women
40
—
UK: United Kingdom; USA: United States of America.
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