Review Article
Clinical Features and Treatments of Syphilitic Uveitis: A Systematic Review and Meta-Analysis
Table 1
Study characteristics and patient demographics.
| | Study | Study design | Study period | Geographical location | Number of patients | Number of eyes | Number of dropouts or loss of follow-up | Age (years), range | Males (%) | Ethnicity (%) |
| | Bollemeijier (2016) | Retrospective | 1984–2013 | Netherlands | 85 | 139 | 10 | 47 (27–73) | 82.4 | Caucasian (78.8), Surinam black (8.2),
African American (2.3), Asian (8.2), Surinam Indian (2.3) | | Dai (2016) | Retrospective | 2011-2012 | China | 25 | 41 | Unknown | 53 (33–70) | 72 | Chinese (100.0) | | Fonollosa (2016) | Retrospective | 2000–2012 | Spain | 50 | 93 | 0 | 41 (19–76) | 61 | — | | Sahin (2016) | Retrospective | 2012–2014 | Turkey | 12 | 17 | 0 | 43.75 (8–67) | 58.3 | Caucasian (100.0) | | Tsuboi (2016) | Retrospective | 1997–2015 | Japan | 20 | 30 | 4 | 41 (32.5–46.5) | 100 | Japanese (100.0) | | Zhang (2016) | Retrospective | 2012–2015 | China | 15 | 26 | 0 | 50 (35–68) | 60 | Chinese (100.0) | | Lee (2015) | Retrospective | 2008–2014 | USA | 16 | 29 | 2 | 48.5 (20–63) | 100 | Black (25.0), Hispanic
(56.2), white (12.5), others (6.2) | | Moradi (2015) | Retrospective | 1984–2014 | USA | 35 | 61 | 4 | 45 (24–80) | 74.3 | African American (60.0),
Caucasian (40.0) | | Northey (2015) | Retrospective | 2007–2012 | Australia | 25 | 37 | 50% lost after 3 months | 41 (24–81) | 92 | — | | Shen (2015) | Retrospective | 2009–2014 | China | 13 | 21 | 4 | 50.3 ± 5.9 (37–61) | 53.8 | Chinese (100.0) | | Mathew (2014) | Prospective | 2009–2011 | UK | 41 | 63 | 0 | 47.5 (20.6–75.1) | 90.2 | Caucasian (90.2), Afro
Caribbean (7.1); Arab (2.4) | | Rodrigues (2014) | Retrospective | 2012 (Mar. to Oct.) | Brazil | 12 | 19 | Unknown | 38.5 (28–55) | 91.6 | — | | Yap (2014) | Retrospective | 2004–2009 | Singapore | 12 | 18 | 2 only at 1 month | 49.5 (24–84) | 91.7 | Chinese (75.0), Malays
(16.7), Indian (8.3) | | Restivo (2013) | Retrospective | 2004–2010 | Italy | 14 | 21 | 0 | 46.2 ± 10.4 (26–66) | 92.9 | — | | Eandi (2012) | Retrospective | — | USA, Europe | 16 | 25 | Unknown | 40 (28–57) | 87.5 | Non-Latino white (93.8),
black (6.3) | | Yang (2012) | Retrospective | 2004–2011 | China | 19 | 35 | 0 | 41.8 (19–70) | 57.9 | Asian (100.0) | | Balaskas (2011) | Retrospective | 1999–2009 | Switzerland | 26 | 42 | 3 | 45 (33–80) | 69.2 | Caucasian (80.8), African
(15.4), Asian (3.8) | | Li (2011) | Retrospective | 1991–2009 | USA | 13 | 24 | 1 | 40 (30–67) | 100 | — | | Hughes (2010) | Retrospective | 2006–2009 | Australia | 13 | 19 | 0 | 41.7 (29–29) | 92.3 | — | | Li (2010) | Retrospective | 92% after 2000 | Not mentioned | 13 | 22 | 2-3 probably lost | 38 (26–55) | 100 | — | | Kunkel (2009) | Retrospective | 1998–2006 | Germany | 24 | 41 | 11 | 42.4 ± 2.5 (); 41.6 ± 3.0 () | 91.7 | — | | Fonollosa (2009) | Retrospective | 2005–2007 | Spain | 12 | 18 | 0 | 47 (26–76) | 83.3 | — | | Anshu (2008) | Retrospective | 1995–2006 | Singapore | 22 | 29 | Unknown | 52.7 (18–78) | 77.3 | — | | Hong (2007) | Retrospective | 1992–2004 | Taiwan | 8 | 14 | 0 | 57.7 (32–82) | 87.5 | — | | Parc (2007) | Retrospective | 2001–2004 | France | 10 | 11 | 6/10 lost after 3 months | 41.2 ± 9.9 (28–59) | 100 | — | | Tran (2005) | Retrospective | 2001–2003 | France | 12 | 20 | 3 | 40 (28–56) | 100 | — | | Shalaby (1997) | Retrospective | 1983–1995 | USA | 13 | 23 | 5 | 37 (?–?) | 92.3 | — | | Ormerod (2001) | Retrospective | 1990–1993 | USA | 21 | 40 | 2 | 51 (29–72) | 61.9 | Black (76.2), no data (23.8) | | Browning (2000) | Retrospective | 1986–1999 | USA | 14 | 24 | 0 | 42 (28–69) | 71.4 | African American (78.6), Caucasian (21.4) | | Villanueva (2000) | Retrospective | 1993–1996 | USA | 20 | Not mentioned | 6 | 58 ± 14 (29–70) | 40 | Black (100.0) | | Deschenes (1992) | Retrospective | 1986–1990 | Canada | 14 | 24 | Unknown | Mean: 50 for men, 63 for women | 64.3 | — | | Tamesis (1990) | Retrospective | 1983–1989 | USA | 25 | 36 | Unknown | Mean: 47 for men, 57 for women | 40 | — |
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UK: United Kingdom; USA: United States of America.
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