Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4
Table 1
Relationships among administered agents, infection onset severity, and duration from last glaucoma surgery to bleb-related infection onset.
(%)
Stage
Duration (y)
Median (IQR, min/max)
Median (IQR, min/max)
Steroid
Yes
13 (12.5)
3.0 (2.0–4.0, 1.0/4.0)
0.012
2.0 (1.1–6.1, 0.3/9.8)
0.030
No
91 (87.5)
1.0 (1.0–3.0, 1.0/4.0)
5.8 (3.0–9.1, 0.3/41.4)
0.1% BM eye drops
6 (5.8)
3.5 (3.0–4.0, 2.0/4.0)
0.013
1.8 (1.4–3.2, 1.1/6.1)
0.036
0.02 and 0.1% FM eye drops
6 (5.8)
1.5 (1.0–2.8, 1.0/4.0)
2.3 (0.5–7.7, 0.3/9.5)
Antibiotic
Yes
42 (40.4)
2.0 (1.0–3.0, 1.0/4.0)
0.362
6.4 (3.5–10.1, 0.3/41.4)
0.025
No
62 (59.6)
1.0 (1.0–3.0, 1.0/4.0)
3.9 (2.0–7.2, 0.3/17.5)
0.5% LVFX eye dropsa
28 (26.9)
1.5 (1.0–3.0, 1.0/4.0)
0.375
6.2 (3.2–9.5, 0.3/41.4)
0.049
0.3% OFLX ointment
6 (5.8)
3.0 (1.3-4.0, 1.0/4.0)
10.5 (6.8–12.7, 3.6/14.7)
Sodium hyaluronate
Yes
16 (15.4)
2.0 (1.0–3.0, 1.0/4.0)
0.649
6.1 (4.1–9.0, 0.9/12.0)
0.351
No
88 (85.6)
1.0 (1.0–3.0, 1.0/4.0)
4.7 (2.2–9.0, 0.3/41.4)
IQR: interquartile range; BM: betamethasone; FM: fluorometholone; LVFX: levofloxacin; OFLX: ofloxacin. value for comparing two groups (Mann–Whitney U test) and three groups (Kruskal–Wallis test). aOne eye administered with other antibiotics simultaneously are excluded.
