Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4
Table 3
Characteristics of the eyes administered steroids, antibiotics, or sodium hyaluronate.
Steroid
Antibiotic
Sodium hyaluronate
Yes
No
Yes
No
Yes
No
Median (IQR)
Median (IQR)
Median (IQR)
Median (IQR)
Median (IQR)
Median (IQR)
IOP(mmHg)
Preinfection
17 (13–19)
0.844
10 (8–12)
0.065
11 (8–14)
0.182
9 (7–13)
0.191
11 (7–14)
1.000
10 (8–13)
0.562
Postinfection
19 (15–20)
11 (8–15)
13 (10–18)
11 (8–15)
13 (10–16)
12 (8–16)
LogMAR VA
Preinfection
0.8 (0.4–1.2)
0.058
0.2 (0.0-1.0)
0.055
0.5 (0.0-1.5)
0.029
0.1 (0.0-1.0)
0.001
0.5 (0.1–1.8)
0.281
0.2 (0.0-1.0)
0.001
Postinfection
1.7 (1.1-2.9)
0.7 (0.0–2.7)
1.3 (0.1-2.3)
0.4 (0.0–2.7)
1.3 (0.3–2.7)
0.7 (0.0–2.7)
(%)
(%)
(%)
(%)
(%)
(%)
Bleb morphology
Total 100 (100%)
13 (13.0)
87 (87.0)
39 (39.0)
61 (61.0)
16 (16.0)
84 (84.0)
Cystic
5 (5.0)
42 (42.0)
0.681
19 (19.0)
28 (28.0)
0.506
8 (8.0)
39 (39.0)
0.849
Diffuse
8 (8.0)
40 (40.0)
20 (20.0)
28 (28.0)
7 (7.0)
41 (41.0)
Encapsulated
0 (0.0)
4 (4.0)
0 (0.0)
4 (4.0)
1 (1.0)
3 (3.0)
Flat
0 (0.0)
1 (1.0)
0 (0.0)
1 (1.0)
0 (0.0)
1 (1.0)
Bleb vascularity
Total 99 (100%)
13 (13.1)
86 (86.9)
38 (38.4)
61 (61.6)
16 (16.2)
83 (83.8)
Avascular
9 (9.1)
68 (68.7)
0.469
33 (33.3)
44 (44.4)
0.081
12 (12.1)
65 (65.7)
0.818
Partial avascular
4 (4.0)
16 (16.2)
5 (5.1)
15 (15.2)
4 (4.0)
16 (16.2)
Vascular
0 (0.0)
2 (2.0)
0 (0.0)
2 (2.0)
0 (0.0)
2 (2.0)
Bleb leakage
Total 101 (100%)
13 (12.9)
88 (87.1)
41 (40.6)
60 (59.4)
16 (15.8)
85 (84.2)
Leak (+)
4 (4.0)
37 (36.6)
0.445
24 (23.8)
17 (16.8)
0.003
8 (7.9)
33 (32.7)
0.406
Leak (−)
9 (8.9)
51 (50.5)
17 (16.8)
43 (42.6)
8 (7.9)
52 (51.5)
IOP: intraocular pressure; VA: visual acuity. P1: value for IOP and LogMAR distribution (preinfection versus 12 months postinfection by Wilcoxon signed-rank test). : value for bleb morphology, bleb vascularity, and bleb leakage variables (Mann–Whitney U tests). Avascular: avascular area of the blebs is ≥50%; Partial avascular: avascular area of the blebs is <50% but the blebs are not vascular; Vascular: blebs have no avascular area. Leak (+): number of patients with history of bleb leak prior to infection; Leak (−): number of patients without bleb leak prior to infection.
