Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys
Additive IOP-lowering effect of ripasudil with timolol. Male albino rabbits were administered 50 μL of vehicle (○), 0.4% ripasudil (●), 0.5% timolol (△), or 0.4% ripasudil + 0.5% timolol (◆) into one eye (). The contralateral eye was not treated. IOP were measured using pneumotonometers prior to the experiments and 0.5, 1, 2, 3, 4, and 5 h after instillation. For combined use of ophthalmic agents, 0.5% timolol was administered 5 min after instillation of 0.4% ripasudil. All data are presented as means ± SEs. ,†, compared with vehicle and 0.4% ripasudil, respectively (Tukey’s multiple comparison test).
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