Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys

Figure 5

Additive IOP-lowering effect of ripasudil with latanoprost. Male cynomolgus monkeys were administered 20 μL of 0.4% ripasudil (●), 0.005% latanoprost (△), or 0.4% ripasudil + 0.005% latanoprost (◆) into one eye (). The contralateral eye was not treated. IOP were measured using pneumotonometers prior to the experiments and 1, 2, 4, and 6 h after instillation. For combined use of ophthalmic agents, 0.005% latanoprost was administered 5 min after instillation of 0.4% ripasudil. All data are presented as means ± SEs. ^,†, compared with 0.005% latanoprost and ripasudil, respectively (Tukey’s multiple comparison test).