Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys

Figure 6

Additive IOP-lowering effect of ripasudil with latanoprost/timolol fixed combination. Monkeys were administered vehicle + 0.005% latanoprost/0.5% timolol fixed combination (▲), or 0.4% ripasudil + 0.005% latanoprost/0.5% timolol fixed combination (◆) into one eye (). IOP were measured before and 1, 2, 3, 4, 6, and 8 h after instillation. 0.005% latanoprost/0.5% timolol fixed combination was administered 5 min after instillation of vehicle or 0.4% ripasudil. All data are presented as means ± SEs. , compared with vehicle + 0.005% latanoprost/0.5% timolol fixed combination (Student’s t-test).