Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2017, Article ID 7079645, 8 pages
https://doi.org/10.1155/2017/7079645
Research Article

Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys

Tokyo New Drug Research Laboratories, Kowa Co. Ltd., 2-17-43 Noguchicho, Higashimurayama, Tokyo 189-0022, Japan

Correspondence should be addressed to Yoshio Kaneko; pj.oc.awok@okenakoy

Received 28 December 2016; Accepted 27 March 2017; Published 30 April 2017

Academic Editor: Padmanabhan Pattabiraman

Copyright © 2017 Yoshio Kaneko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Ishizaki, M. Maekawa, K. Fujisawa et al., “The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase,” The EMBO Journal, vol. 15, no. 8, pp. 1885–1893, 1996. View at Google Scholar
  2. O. Nakagawa, K. Fujisawa, T. Ishizaki, Y. Saito, K. Nakao, and S. Narumiya, “ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice,” FEBS Letters, vol. 392, no. 2, pp. 189–193, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Fukiage, K. Mizutani, Y. Kawamoto, M. Azuma, and T. R. Shearer, “Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction,” Biochemical and Biophysical Research Communications, vol. 288, no. 2, pp. 296–300, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Shimokawa and A. Takeshita, “Rho-kinase is an important therapeutic target in cardiovascular medicine,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 9, pp. 1767–1775, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Sagawa, H. Terasaki, M. Nakamura et al., “A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats,” Experimental Neurology, vol. 205, no. 1, pp. 230–240, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. H. B. Tan, Y. S. Zhong, Y. Cheng, and X. Shen, “Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage,” International Journal Ophthalmology, vol. 4, no. 6, pp. 652–657, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Bertrand, M. Winton, N. Rodriguez-Hernandez, R. B. Campenot, and L. McKerracher, “Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats,” The Journal of Neuroscience, vol. 25, no. 5, pp. 1113–1121, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Stiles, V. Kurisetty, D. C. Mitchell, and B. A. Bryan, “Rho kinase proteins regulate global miRNA expression in endothelial cells,” Cancer Genomics Proteomics, vol. 10, no. 6, pp. 251–263, 2013. View at Google Scholar
  9. M. Waki, Y. Yoshida, T. Oka, and M. Azuma, “Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase,” Current Eye Research, vol. 22, no. 6, pp. 470–474, 2001. View at Google Scholar
  10. M. Tamura, H. Nakao, H. Yoshizaki et al., “Development of specific Rho-kinase inhibitors and their clinical application,” Biochimica et Biophysica Acta, vol. 1754, no. 1-2, pp. 245–252, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Yokota, K. Utsunomiya, K. Taniguchi, A. Gojo, H. Kurata, and N. Tajima, “Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina,” Japanese Journal of Ophthalmology, vol. 51, no. 6, pp. 424–430, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Arita, Y. Hata, S. Nakao et al., “Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage,” Diabetes, vol. 58, no. 1, pp. 215–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Hollanders, T. Van Bergen, N. Kindt et al., “The effect of AMA0428, a novel and potent ROCK inhibitor, in a model of neovascular age-related macular degeneration,” Investigative Ophthalmology & Visual Science, vol. 56, no. 2, pp. 1335–1348, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Zandi, S. Nakao, K. H. Chun et al., “ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration,” Cell Reports, vol. 10, no. 7, pp. 1173–1186, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. H. J. Cho and J. Yoo, “Rho activation is required for transforming growth factor-beta-induced epithelial-mesenchymal transition in lens epithelial cells,” Cell Biology International, vol. 31, no. 10, pp. 1225–1230, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Okumura, N. Koizumi, M. Ueno et al., “The new therapeutic concept of using a rho kinase inhibitor for the treatment of corneal endothelial dysfunction,” Cornea, vol. 30, Supplement 1, pp. S54–S59, 2011. View at Publisher · View at Google Scholar
  17. Y. Zheng, H. Bando, Y. Ikuno et al., “Involvement of rho-kinase pathway in contractile activity of rabbit RPE cells in vivo and in vitro,” Investigative Ophthalmology & Visual Science, vol. 45, no. 2, pp. 668–674, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Hirata, M. Inatani, Y. Inomata et al., “Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 246, no. 1, pp. 51–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Honjo, H. Tanihara, M. Inatani et al., “Effects of Rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility,” Investigative Ophthalmology & Visual Science, vol. 42, no. 2, pp. 137–144, 2001. View at Google Scholar
  20. M. Honjo, M. Inatani, N. Kido et al., “Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes,” Archives of Ophthalmology, vol. 119, no. 8, pp. 1171–1178, 2001. View at Publisher · View at Google Scholar
  21. H. A. Quigley, “Open-angle glaucoma,” The New England Journal of Medicine, vol. 328, no. 15, pp. 1097–1106, 1993. View at Publisher · View at Google Scholar
  22. R. van der Valk, C. A. Webers, J. S. Schouten, M. P. Zeegers, F. Hendrikse, and M. H. Prins, “Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials,” Ophthalmology, vol. 112, no. 7, pp. 1177–1185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. Japanese Ophthalmologic Society, “The Japan glaucoma society guidelines for glaucoma (3rd edition),” Nihon Ganka Gakkai Zasshi, vol. 116, no. 1, pp. 3–46, 2012, (in Japanese). View at Google Scholar
  24. Y. Nakai, “Current status of glaucoma therapy at private practices and a private ophthalmology hospital,” Atarashii Ganka (J. Eye), vol. 25, no. 11, pp. 1581–1585, 2008, (in Japanese). View at Google Scholar
  25. K. P. Garnock-Jones, “Ripasudil: first global approval,” Drugs, vol. 74, no. 18, pp. 2211–2215, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Isobe, K. Mizuno, Y. Kaneko, M. Ohta, T. Koide, and S. Tanabe, “Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits,” Current Eye Research, vol. 39, no. 8, pp. 813–822, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Kaneko, M. Ohta, T. Inoue et al., “Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm’s canal endothelial cells,” Scientific Reports, vol. 6, p. 19640, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Tanihara, T. Inoue, T. Yamamoto et al., “Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study,” Acta Ophthalmologica, vol. 93, no. 4, pp. e254–e260, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Tanihara, T. Inoue, T. Yamamoto et al., “Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension,” American Journal of Ophthalmology, vol. 156, no. 4, pp. 731–736, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Tanihara, T. Inoue, T. Yamamoto et al., “Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115,” JAMA Ophthalmology, vol. 131, no. 10, pp. 1288–1295, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Tanihara, T. Inoue, T. Yamamoto et al., “Additive intraocular pressure-lowering effects of the Rho kinase inhibitor ripasudil (K-115) combined with timolol or latanoprost: a report of 2 randomized clinical trials,” JAMA Ophthalmology, vol. 133, no. 7, pp. 755–761, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Tanihara, T. Inoue, T. Yamamoto et al., “One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension,” Acta Ophthalmologica, vol. 94, no. 1, pp. e26–e34, 2016. View at Publisher · View at Google Scholar · View at Scopus
  33. Z. Lu, D. R. Overby, P. A. Scott, T. F. Freddo, and H. Gong, “The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes,” Experimental Eye Research, vol. 86, no. 2, pp. 271–281, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Koga, T. Koga, M. Awai, J. Tsutsui, B. Y. Yue, and H. Tanihara, “Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells,” Experimental Eye Research, vol. 82, no. 3, pp. 362–370, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Kameda, T. Inoue, M. Inatani et al., “The effect of Rho associated protein kinase inhibitor on monkey Schlemm’s canal endothelial cells,” Investigative Ophthalmology & Visual Science, vol. 53, no. 6, pp. 3092–3103, 2012. View at Publisher · View at Google Scholar
  36. D. O. Zamora and J. W. Kiel, “Topical proparacaine and episcleral venous pressure in the rabbit,” Investigative Ophthalmology & Visual Science, vol. 50, no. 6, pp. 2949–2952, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Mizuno, T. Koide, N. Saito et al., “Topical nipradilol: effects on optic nerve head circulation in humans and periocular distribution in monkeys,” Investigative Ophthalmology & Visual Science, vol. 43, no. 10, pp. 3243–3250, 2002. View at Google Scholar
  38. T. Yoshitomi, K. Yamaji, H. Ishikawa, and Y. Ohnishi, “Vasodilatory effects of nipradilol, an alpha- and beta-adrenergic blocker with nitric oxide releasing action, in rabbit ciliary artery,” Experimental Eye Research, vol. 75, no. 6, pp. 669–676, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Kanno, M. Araie, K. Tomita, and K. Sawanobori, “Effects of topical nipradilol, a beta-blocking agent with alpha-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation,” Investigative Ophthalmology & Visual Science, vol. 39, no. 5, pp. 736–743, 1998. View at Google Scholar
  40. T. Kida, T. Sugiyama, S. Harino, K. Kitanishi, and T. Ikeda, “The effect of nipradilol, an alpha-beta blocker, on retinal blood flow in healthy volunteers,” Current Eye Research, vol. 23, no. 2, pp. 128–132, 2001. View at Google Scholar
  41. J. E. Grunwald, “Effect of two weeks of timolol maleate treatment on the normal retinal circulation,” Investigative Ophthalmology & Visual Science, vol. 32, no. 1, pp. 39–45, 1991. View at Google Scholar
  42. Y. Tamaki, M. Araie, K. Tomita, A. Tomidokoro, and M. Nagahara, “Effects of topical adrenergic agents on tissue circulation in rabbit and human optic nerve head evaluated with laser speckle tissue circulation analyzer,” Survey of Ophthalmology, vol. 42, Supplement 1, pp. S52–S63, 1997. View at Google Scholar
  43. S. Nakabayashi, M. Kawai, T. Yoshioka et al., “Effect of intravitreal Rho kinase inhibitor ripasudil (K-115) on feline retinal microcirculation,” Experimental Eye Research, vol. 139, pp. 132–135, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. T. Sugiyama, M. Shibata, S. Kajiura et al., “Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits,” Investigative Ophthalmology & Visual Science, vol. 52, no. 1, pp. 64–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Tokushige, M. Waki, Y. Takayama, and H. Tanihara, “Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats,” Current Eye Research, vol. 36, no. 10, pp. 964–970, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. E. Yoles, L. A. Wheeler, and M. Schwartz, “Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration,” Investigative Ophthalmology & Visual Science, vol. 40, no. 1, pp. 65–73, 1999. View at Google Scholar
  47. T. Krupin, J. M. Liebmann, D. S. Greenfield, R. Ritch, and S. Gardiner, “A randomized trial of brimonidine versus timolol in preserving visual function: results from the low-pressure glaucoma treatment study,” American Journal of Ophthalmology, vol. 151, no. 4, pp. 671–681, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Yamamoto, K. Maruyama, N. Himori et al., “The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma,” Investigative Ophthalmology & Visual Science, vol. 55, no. 11, pp. 7126–7136, 2014. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Tura, F. Schuettauf, P. P. Monnier, K. U. Bartz-Schmidt, and S. Henke-Fahle, “Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina,” Investigative Ophthalmology & Visual Science, vol. 50, no. 1, pp. 452–461, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. Kitaoka, Y. Kitaoka, T. Kumai et al., “Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina,” Brain Research, vol. 1018, no. 1, pp. 111–118, 2004. View at Publisher · View at Google Scholar · View at Scopus
  51. P. Y. Mong, C. Petrulio, H. L. Kaufman, and Q. Wang, “Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells,” Journal of Immunology, vol. 180, no. 1, pp. 550–558, 2008. View at Google Scholar
  52. Y. Nakamura, S. Hirano, K. Suzuki, K. Seki, T. Sagara, and T. Nishida, “Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells,” Investigative Ophthalmology & Visual Science, vol. 43, no. 11, pp. 3465–3472, 2002. View at Google Scholar
  53. Y. Takai, M. Tanito, and A. Ohira, “Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract,” Investigative Ophthalmology & Visual Science, vol. 53, no. 1, pp. 241–247, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Ohira, T. Inoue, K. Iwao, E. Takahashi, and H. Tanihara, “Factors influencing aqueous proinflammatory cytokines and growth factors in uveitic glaucoma,” PloS One, vol. 11, no. 1, article e0147080, 2016. View at Publisher · View at Google Scholar
  55. P. Agarwal, A. M. Daher, and R. Agarwal, “Aqueous humor TGF-β2 levels in patients with open-angle glaucoma: a meta-analysis,” Molecular Vision, vol. 21, pp. 612–620, 2015. View at Google Scholar
  56. T. Fujimoto, T. Inoue, T. Kameda et al., “Involvement of RhoA/Rho-associated kinase signal transduction pathway in dexamethasone-induced alterations in aqueous outflow,” Investigative Ophthalmology & Visual Science, vol. 53, no. 11, pp. 7097–7108, 2012. View at Publisher · View at Google Scholar · View at Scopus