Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys

Table 1

Additive effect by ripasudil for categories of glaucoma therapeutic agents.

Categories	Target	Additive effect with ripasudil
β-Blockers	Suppression of aqueous humor production	IOP reduction; Prolonged duration
CAI		IOP reduction; Prolonged duration
Combination of β-blockers and CAI		IOP reduction; Prolonged duration
PG analogs	Promotion of uveoscleral outflow	IOP reduction; Prolonged duration
α2-Agonists	Suppression of aqueous humor production and promotion of uveoscleral outflow	IOP reduction; Prolonged duration
αβ-Blockers		Prolonged duration
Combination of PG analogs and β-blockers		IOP reduction; Prolonged duration