Journal of Ophthalmology / 2017 / Article / Tab 1

Review Article

Peripheral Ulcerative Keratitis Associated with Autoimmune Disease: Pathogenesis and Treatment

Table 1

The therapy of PUK associated with autoimmune diseases.

TherapyClassificationAgentTarget

Topical therapyCorticosteroidPrednisoloneImmune system [74, 75]
ImmunosuppressantCyclosporine AAntigen-triggered signal transduction in T lymphocytes and expression of many lymphokines (IL-2) and antiapoptotic proteins [76]
Collagenase inhibitorsl% medroxyprogesteroneCollagenase [41, 77]
20% acetylcysteine

Surgical therapyCyanoacrylate glue, conjunctival flap, lamellar patch flap, or penetrating keratoplasty [71],
conjunctivectomy combined with cryotherapy (mentioned in SLE) [111]

Systemic therapyCorticosteroidPrednisoloneImmune system [74, 75]
ImmunosuppressantMTXImmune system [2]
CTX
Cyclosporine
Azathioprine
Biologic therapyEtanerceptTNF-α [80]
Infliximab
Adalimumab
Golimumab
DMARDs
RituximabB cell [81, 84, 9193]
Etanercept
Adalimumab
AbataceptT cell [84]
AnakinraIL-1 [84]
TocilizumabIL-6 [84]
IxekizumabIL-17 [94–97]
Secukinumab
Brodalumab
UstekinumabIL-12/IL-23 [80, 98–100]
GuselkumabIL-23 [80, 98–100]
Belimumab (mentioned in SLE)BAFF [108]
INF (interferon alpha and gamma), TLRs, pDCs, and JAK/STAT inhibitors (mentioned in SLE)INF (interferon alpha and gamma), TLRs, pDCs, and JAK/STAT

Most of the therapies are similar. However, there are some different places among these diseases.

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