Research Article

Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells

Table 4

Gene ontology of downregulated genes in Y-27632-treated TM cells.

OntologyTermChanged genesTotal genes value

Molecular functionEndonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5′-phosphomonoesters2 (0)13 (0)0.00279
Biological processAntigen processing and presentation of peptide or polysaccharide antigen via MHC class II2 (2)16 (14)0.00421
Cellular componentMHC class II protein complex2 (2)18 (18)0.00606
Molecular functionD-Dopachrome decarboxylase activity1 (1)1 (1)0.01065
Molecular functionGlucose 1-dehydrogenase activity1 (1)1 (1)0.01065
Molecular functionGlucose-6-phosphate dehydrogenase activity1 (1)1 (1)0.01065
Molecular functionDeoxyribonuclease I activity1 (1)1 (1)0.01065
Molecular function3′-Phosphoadenosine 5′-phosphosulfate transmembrane transporter activity1 (1)1 (1)0.01065
Biological processOlfactory behavior1 (1)1 (1)0.01091
Biological processPositive regulation of dopamine receptor signaling pathway1 (1)1 (1)0.01091
Biological processRegulation of dopamine receptor signaling pathway1 (0)1 (0)0.01091
Biological process3′-Phosphoadenosine 5′-phosphosulfate transport1 (1)1 (1)0.01091
Biological processNegative regulation of neuron apoptosis2 (2)28 (28)0.01148
Cellular componentMHC protein complex2(0)26(0)0.01171
Molecular functionToxin binding1 (1)2 (2)0.01594
Molecular functionC2H2 zinc finger domain binding1 (1)2 (2)0.01594
Molecular functionDopachrome isomerase activity1 (1)2 (2)0.01594
Molecular function6-Phosphogluconolactonase activity1 (1)2 (2)0.01594
Molecular functionHedgehog receptor activity1 (1)2 (2)0.01594
Molecular functionDihydrofolate reductase activity1 (1)2 (2)0.01594
Molecular functionPurine nucleoside transmembrane transporter activity1 (0)2 (1)0.01594
Biological processCytolysis by symbiont of host cells1 (0)2 (0)0.01632
Biological processCytolysis of cells in other organism during symbiotic interaction1 (0)2 (0)0.01632
Biological processCytolysis of cells of another organism1 (0)2 (0)0.01632
Biological processDisruption by symbiont of host cells1 (0)2 (0)0.01632
Biological processHemolysis by symbiont of host erythrocytes1 (1)2 (2)0.01632
Biological processHemolysis of cells in other organism1 (0)2 (0)0.01632
Biological processHemolysis of cells in other organism during symbiotic interaction1 (0)2 (0)0.01632
Biological processKilling by symbiont of host cells1 (0)2 (0)0.01632
Biological processMaintenance of mitochondrion location1 (1)2 (2)0.01632
Biological processModification by organism of cell membrane in other organism during symbiotic interaction1 (0)2 (0)0.01632
Biological processModification by symbiont of host cell membrane1 (0)2 (0)0.01632
Biological processModification by symbiont of host cellular component1 (0)2 (0)0.01632
Biological processModification by symbiont of host structure1 (0)2 (0)0.01632
Biological processModification of cellular component in other organism during symbiotic interaction1 (0)2 (0)0.01632
Biological processModification of structure of other organism during symbiotic interaction1 (0)2 (0)0.01632
Biological processCaveola assembly1 (1)2 (2)0.01632
Biological processMembrane raft assembly1 (0)2 (0)0.01632
Biological processPositive regulation of G-protein coupled receptor protein signaling pathway1 (0)2 (1)0.01632
Biological processChromatin-mediated maintenance of transcription1 (1)2 (2)0.01632
Biological processPositive regulation of gene expression, epigenetic1 (0)2 (0)0.01632
Biological processncRNA catabolic process1 (0)2 (0)0.01632
Biological processrRNA catabolic process1 (1)2 (2)0.01632
Biological processPurine nucleoside transport1 (0)2 (1)0.01632
Biological processStriated muscle cell differentiation2 (1)38 (5)0.0199
Biological processAntigen processing and presentation2 (2)38 (32)0.0199
Molecular functionCopper ion binding2 (2)39 (38)0.01996
Molecular functionEndodeoxyribonuclease activity, producing 5′-phosphomonoesters1 (0)3 (1)0.0212
Cellular componentMembrane24 (17)2769 (1768)0.02168
Biological processMaintenance of organelle location1 (0)3 (0)0.02171
Biological processMelanin biosynthetic process1 (1)3 (3)0.02171
Biological processMelanin metabolic process1 (0)3 (0)0.02171
Biological processEndoplasmic reticulum calcium ion homeostasis1 (1)3 (1)0.02171
Biological processMulticellular organismal water homeostasis1 (0)3 (0)0.02171
Biological processRenal water homeostasis1 (1)3 (1)0.02171
Biological processPositive regulation of Rac protein signal transduction1 (1)3 (3)0.02171
Biological processApoptosis7 (3)522 (189)0.0221
Biological processProgrammed cell death7 (0)525 (2)0.02273
Cellular componentExtrinsic to internal side of plasma membrane1 (1)3 (3)0.02347
Cellular componentSpectrin1 (1)3 (3)0.02347
Molecular functionEndonuclease activity2 (2)43 (30)0.02378
Molecular functionNucleoside transmembrane transporter activity1 (0)4 (1)0.02643
Biological processRegulation of neuron apoptosis2 (0)45 (2)0.02693
Biological processDetection of visible light1 (1)4 (1)0.02706
Biological processChemosensory behavior1 (0)4 (3)0.02706
Biological processProtein maturation by protein folding1 (1)4 (4)0.02706
Biological processCellular chaperone-mediated protein complex assembly1 (1)4 (2)0.02706
Biological processMitochondrial outer membrane translocase complex assembly1 (1)4 (4)0.02706
Biological processOuter mitochondrial membrane organization1 (0)4 (0)0.02706
Biological processGlycine biosynthetic process1 (1)4 (2)0.02706
Cellular componentMembrane part21 (0)2325 (1)0.02771
Biological processCellular membrane organization4 (0)212 (30)0.02909
Biological processMembrane organization4 (0)212 (0)0.02909
Biological processNeuron apoptosis2 (0)48 (3)0.03021
Biological processNeuron death2 (0)48 (0)0.03021
Biological processMuscle cell differentiation2 (0)49 (1)0.03134
Biological processDisruption of cells of other organism during symbiotic interaction1 (0)5 (0)0.03239
Biological processKilling of cells in other organism during symbiotic interaction1 (0)5 (0)0.03239
Biological processWater homeostasis1 (0)5 (1)0.03239
Biological processEndoplasmic reticulum organization1 (1)5 (5)0.03239
Biological processMembrane raft organization1 (0)5 (1)0.03239
Biological processPinocytosis1 (1)5 (2)0.03239
Biological processNucleoside transport1 (0)5 (2)0.03239
Biological processResponse to light stimulus2 (0)51 (8)0.03364
Biological processCell death7 (0)578 (68)0.03597
Biological processVesicle-mediated transport5 (2)336 (120)0.03622
Biological processDeath7 (0)579 (0)0.03626
Biological processPositive regulation of signaling pathway3 (0)133 (0)0.03743
Biological processModification by host of symbiont morphology or physiology1 (0)6 (0)0.03769
Biological processER overload response1 (1)6 (5)0.03769
Biological processRegulation of Rac protein signal transduction1 (0)6 (1)0.03769
Molecular functionActin binding3 (3)139 (121)0.0394
Cellular componentHOPS complex1 (1)6 (6)0.04072
Molecular functionIntramolecular oxidoreductase activity, transposing C=C bonds1 (0)7 (0)0.04196
Biological processDetection of light stimulus1 (0)7 (0)0.04296
Biological processMetabotropic glutamate receptor signaling pathway1 (1)7 (4)0.04296
Biological processRegulation of synaptic transmission, GABAergic1 (1)7 (2)0.04296
Cellular componentInternal side of plasma membrane1 (0)7 (4)0.04641
Molecular functionScavenger receptor activity1 (1)8 (8)0.04708
Biological processInteraction with symbiont1 (0)8 (1)0.0482
Biological processModification by symbiont of host morphology or physiology1 (0)8 (0)0.0482
Biological processChaperone-mediated protein complex assembly1 (0)8 (4)0.0482
Biological processPositive regulation of Ras protein signal transduction1 (0)8 (4)0.0482
Biological processPositive regulation of small GTPase-mediated signal transduction1 (0)8 (0)0.0482
Biological processSynaptic transmission, GABAergic1 (0)8 (1)0.0482
Biological processActin filament capping1 (1)8 (6)0.0482
Biological processPentose-phosphate shunt1 (1)8 (7)0.0482
Biological processCalcium ion transport2 (1)63 (41)0.04876
Cellular componentIntrinsic to membrane17 (0)1867 (20)0.0491